Similac Pro-Advance™

Complete nutrition for baby’s first year, with added 2’-FL HMO prebiotic for immune support


Unlike other formulas, we have 2’-FL Human Milk Oligosaccharide* (HMO), an immune-nourishing prebiotic that circulates throughout the body. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant than ever before.


Moms reported a reduction in fussiness, gassiness, and crying after just one day of feeding.

2’-FL HMO facts:

  • Naturally abundant in most breast milk
  • Backed by more than 15 years of extensive research
  • Adds another layer to Similac’s already proven immune support

Similac is the first and only leading infant formula brand with no artificial growth hormones. Similac dairy ingredients come from cows that have not been treated with artificial growth hormones.

Similac Pro-Advance is non-GMO§ and has OptiGRO™ , our unique blend of DHA, Lutein, and Vitamin E, to help support your baby’s overall growth, and brain and eye development. Trust Similac Pro-Advance to provide a strong start for your baby’s developing immune system.

* Not from human milk.
After switching to Similac Pro-Advance.
No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
§ Ingredients not genetically engineered.

Moms Reported† a Reduction in Fussiness, Gassiness & Crying After Just 1 Day of Feeding †After Switching to Pro-Advance
Similac Pro-Advance™ Milk-Based Infant Formula Container

Available In:

Similac Pro Advance Formula Powder Can 30.8-oz Powder

Similac Pro-Advance™ Milk-Based Infant Formula Container 1.41-lb Powder

1 QT Ready to Feed Similac Pro Advance Formula Bottle 1-qt Ready to Feed

Moms Reported† a Reduction in Fussiness, Gassiness & Crying After Just 1 Day of Feeding †After Switching to Pro-Advance

Nutrition Information

Powder / 1.41 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

1.41 lb. Similac Pro-Advance™ milk-based powder formula
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Rated 4 out of 5 by from Good formula Haven't had any negative issues with this formula. I definitely like it better than just the advance or total comfort.
Date published: 2018-02-23
Rated 5 out of 5 by from Best formula I've tried. Anything else my baby just can't keep down.
Date published: 2018-02-18
Rated 4 out of 5 by from Love this product Use it for my newborn son. Very disappointed that when I got to wic I have to which brands
Date published: 2018-02-02
Rated 5 out of 5 by from Similac recommend best formula Best formula no problems my son so happy with this similac product. :)
Date published: 2018-01-29
Rated 3 out of 5 by from Rash My baby girl started on Similac ProAdvanced because i had a sample from Strong Moms and the Similac Sensitive was giving her a lot of gas. Since the change she had progressively gotten worse gas, been up all night crying, had diarrhea and now is covered in a rash. I was giving her Similac Sensitive and Similac For Spit Up previously, as I was told to add in a scoop of the SpitUp to the sensitive to help with the spitting up. I am now attempting the pro sensitive formula with the spit up with the hopes that this rash goes away with the other symptoms. Will let you know what happens! I wouldn't recommend the pro advance for any baby who is sensitive to formula. I do think that the Spit Up formula is excellent and really helps with babies who have sensitive gag reflexes or spit up after eating.
Date published: 2018-01-28
Rated 5 out of 5 by from This product is awesome! When I was unable to breastfeed, we used this formula with our newborn. The formula mixes easily, and compared to other formulas we've tried, it didn't cause our baby to experience excess gas or spit up after feeding.
Date published: 2018-01-27
Rated 1 out of 5 by from Sour bellies We have two preemie twins that were originally started on Neosure. One was always constipated, the other always angry. Finally made the switch to Pro-Advance. Worked well at first, but the one that was always angry, was again always angry. The other, who is so chill began getting angry and developed her first diaper rash. Even after applying Desitin after every diaper change, still looks sore and tender. Switched them both to similac-sensitive. We will see. Day 1 complete. Do not recommend, it turned the most chill child, irritable.
Date published: 2018-01-25
Rated 4 out of 5 by from Milk is great except side affects My baby is 3 weeks old and has been on this milk since birth i noticed that her bottom was getting very red so i changed to regular advanced and it cleared up and became liquid so i went back to this and its very red again
Date published: 2018-01-23
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