Similac Pro-Advance™

Complete nutrition for baby’s first year, with added 2’-FL HMO* prebiotic for immune support


Unlike other formulas, we have 2’-FL Human Milk Oligosaccharide* (HMO), an immune-nourishing prebiotic that circulates throughout the body. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant’s than ever before.


2’-FL HMO facts:

  • Naturally abundant in most breast milk
  • Supports the immune system in the gut and it circulates throughout the baby’s body
  • Backed by more than 15 years of extensive research
  • Adds another layer to Similac’s already proven immune support

Similac Pro-Advance also has OptiGRO™ , our unique blend of DHA, Lutein, and Vitamin E, to help support your baby’s overall growth, and brain and eye development. Trust Similac Pro-Advance to provide a strong start for your baby’s developing immune system.

*Not from human milk.

Similac Pro-Advance™ Milk-Based Infant Formula Container

Available In:

Similac Pro-Advance™ Milk-Based Infant Formula Container 1.41-lb Powder

Nutrition Information

Powder / 1.41 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

1.41 lb. Similac Pro-Advance™ milk-based powder formula
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Rated 3 out of 5 by from Wanted this to be good, sadly it wasn't for us Our son was premature. Starting off on 30cal Similac preemie formula for weight gain, that left him uncomfortable and gassy. After discharge and good weight gain, we wanted to switch to something more helpful than a gassy formula. Pro-advance being one of the trial and errors, left our son (one month adjusted) very constipated. We really wanted this to work, sadly it didn't. I rate this as average. Because it does have some better ingredients we were looking for, but it did not help our situation, it actually made it worse.
Date published: 2017-01-14
Rated 5 out of 5 by from Excellent product Was an exclusive pumper for six months. Using this formula made it an easy transition
Date published: 2017-01-13
Rated 5 out of 5 by from Great product! This formula made me feel better about transitioning off of breastfeeding because of the HMO. My daughter has had no problems with the formula!
Date published: 2017-01-07
Rated 2 out of 5 by from 2 month old with excessive spit up after using this product I resently had to switch off of this product because my 2 month old would spit up and get extremely fussy while using the pro advanced for immune health. The doctor had put us on the silver can for immune health thinking it would help with the vomiting and excessive spit up that was caused by the Similac advance in the teal can.
Date published: 2016-12-29
Rated 5 out of 5 by from My baby love this product My baby just born last night and I'm not producing enough milk to breast-feeding. So, i decided to use baby formula. I was worried at first, because why if he doesn't like it? But it wasn't a problem he loved it. Today we left the hospital and I went to Walt Mart for more formula. I bought little bottles called ready to go are amazing. I just shake the bottle and put the nipple ring!
Date published: 2016-12-25
Rated 5 out of 5 by from This formula is amazing I was breastfeeding and decided to introduce formula to my 3 month old baby girl. I circled the store looking at all formulas. I came across similac and was worried of constipation when I saw this brand that was new I decided to try it. My daughter took it right away and has been doing great ever since. She's been on it for about 2 weeks and her stools are as if I'm still breastfeeding her. I would recommend this product. This product really made me feel good about what I'm feeding my baby girl and know she is healthy and doesn't make me feel bad for discontinuing to breastfeed her. I couldn't be more happier with this product. Thank you similac
Date published: 2016-12-02
Rated 5 out of 5 by from great love. its a great product for baby
Date published: 2016-11-29
Rated 4 out of 5 by from Great formula despite how expensive it is. This is great formula. Easy on my baby's tummy unlike the other non-GMO formulas from Similac that leave him gassy and uncomfortable. I'd rate it 5 stars if the cost wasn't so high.
Date published: 2016-11-27
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