Similac Pro-Advance™

Complete nutrition for baby’s first year, with added 2’-FL HMO* prebiotic for immune support


Unlike other formulas, we have 2’-FL Human Milk Oligosaccharide* (HMO), an immune-nourishing prebiotic that circulates throughout the body. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant’s than ever before.


2’-FL HMO facts:

  • Naturally abundant in most breast milk
  • Backed by more than 15 years of extensive research
  • Adds another layer to Similac’s already proven immune support

Similac Pro-Advance is non-GMO and has OptiGRO™ , our unique blend of DHA, Lutein, and Vitamin E, to help support your baby’s overall growth, and brain and eye development. Trust Similac Pro-Advance to provide a strong start for your baby’s developing immune system.

* Not from human milk.
Ingredients not genetically engineered.

Similac Pro-Advance™ Milk-Based Infant Formula Container

Available In:

Similac Pro-Advance™ Milk-Based Infant Formula Container 1.41-lb Powder

Nutrition Information

Powder / 1.41 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

1.41 lb. Similac Pro-Advance™ milk-based powder formula
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Rated 5 out of 5 by from This formula is amazing!!! My baby has had no issues with it and I feel better about not breastfeeding!!! Amazing product!!! The best formula for a baby!!
Date published: 2017-03-21
Rated 5 out of 5 by from Good I had a can to sample with my daughter and she enjoyed it. She was fine on it no reactions I would say the only thing wrong is the price it shouldn't be higher or people who can get it wouldn't have to pay a lot for it. But I enjoyed using it if I could I would use that kind than the kind I am using.
Date published: 2017-03-21
Rated 5 out of 5 by from Great Stuff I'm glad there is a formula to help me feel like I'm giving the best to my son. I tried to breastfeed but my body wouldn't let me. I've been using this since my supply dried up 1 month after my sons birth. Great stuff I highly recommend it!
Date published: 2017-03-16
Rated 5 out of 5 by from Excellent choice of formula My newborn has had no trouble with this formula and barely spits up! She uses the bathroom excellent and has had no tummy trouble or aches! Instantly chugged down a newborn bottle as soon as she was born. I would recommend to any mom 10/10
Date published: 2017-03-16
Rated 5 out of 5 by from My baby loves it!! My little boy does so well with this formula! He rarely spits up and very rarely had tummy aches!
Date published: 2017-03-12
Rated 5 out of 5 by from Great product My baby tolerates this formula very well and if I can't breastfeed him, I can atleast feel like I'm doing the next best thing for him. After failing at breastfeeding, we tried several different formulas and he does best on the pro advance. On the pro advance, he spits up less and his stool closely resembles what it was like when he was breastfeeding. My only complaint would be that I have a hard time finding it. The stores in my area are always out of stock, guess we're not the only ones that like it!
Date published: 2017-03-03
Rated 5 out of 5 by from Great on baby's tummy I had no problems with this product. In fact I noticed my child's stool more regulated vs the standard Similac Advanced. My complaint is that stores don't really sell this product through out the month, only the beginning. So getting my hands on these is really hard. Another issue I have is that it is only sold in a small package instead of a value sized pack with extra formula. I really hope to see a larger size of the Similac Pro-Advanced with the HMO. That would bring a huge smile to my face because I prefer this particular product over the standard Similac Advanced. I also know it supports the little one's immune health more and that is a plus for me. Please make the value size and offer more ways to save on expensive formula!! Thanks so much!
Date published: 2017-03-01
Rated 5 out of 5 by from Excellent I am currently breast feeding and between feedings the pro advance is by far the best formula thus far and has my son sleeping longer my parents love it because the baby does not fuss and this allows me to return to work and or go shopping when needed
Date published: 2017-03-01
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