Similac Pro-Advance™

Complete nutrition for baby’s first year, with added 2’-FL HMO* prebiotic for immune support


Unlike other formulas, we have 2’-FL Human Milk Oligosaccharide* (HMO), an immune-nourishing prebiotic that circulates throughout the body. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant’s than ever before.


2’-FL HMO facts:

  • Naturally abundant in most breast milk
  • Supports the immune system in the gut and it circulates throughout the baby’s body
  • Backed by more than 15 years of extensive research
  • Adds another layer to Similac’s already proven immune support

Similac Pro-Advance also has OptiGRO™ , our unique blend of DHA, Lutein, and Vitamin E, to help support your baby’s overall growth, and brain and eye development. Trust Similac Pro-Advance to provide a strong start for your baby’s developing immune system.

*Not from human milk.

Similac Pro-Advance™ Milk-Based Infant Formula Container

Available In:

Similac Pro-Advance™ Milk-Based Infant Formula Container 1.41-lb Powder

Nutrition Information

Powder / 1.41 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

1.41 lb. Similac Pro-Advance™ milk-based powder formula
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Rated 5 out of 5 by from Hospital started our son on this one and we love it! Our son is just a little over 2 weeks, and he loves this formula. We had no problems with it at all. I like all the ingredients, and even though it was chosen by the hospital, we are sticking with it. No tummy problems, normal spit-ups, and we actually have to cut him off because he loves it so much, I think he can drink way more than 4 ounces. Unless we have to swirtch to another formula, we are happy that we found the best one for our son. The only negative part is that it's hard to find so we might need to switch to Advance Similac. Otherwise, I highly recommend it!!!
Date published: 2017-02-21
Rated 5 out of 5 by from Excellent Formula hands down the best! I started with ready feed 2 oz bottles of pro advance from the 2nd day my LO was born, it is great, no throw ups or problems at all, I just switched to powder pro advance, and no issues at all so far, LO is 1 month old now. Great formula HMO, wish they had this when I was an infant.
Date published: 2017-02-19
Rated 5 out of 5 by from I just gave birth less than 2 wks ago. My sweetie was having trouble latching on and i remebered i had this free sample. We gave her this and for the first time i wasnt worried if she was.getting enough nutrients. I supplemented my breastfeeding with this formula and it was perfect.
Date published: 2017-02-17
Rated 5 out of 5 by from We love Similac My LO loves the new formula. We switched from the Similac advance non GMO a few months ago and it was a very easy transition. I'm not sure that it tastes different but it doesn't smell as metal as the previous formula and my LO can't get the bottle into his hands fast enough.
Date published: 2017-02-16
Rated 2 out of 5 by from Projectile Vomiting, Miserable baby My generally happy baby is now a screaming, crying mess after starting this formula. He projectile vomits all over the place. We switched from the non-GMO Advance formula and it was the biggest mistake ever. I now have a bunch of this horrible formula (I bought a few because I had coupons and it was on sale) and now I don't know what to do. I was a happy Similac customer and now I'm really double thinking my dedication to this brand...
Date published: 2017-02-16
Rated 2 out of 5 by from Concern Mom My baby was started in the NEOSURE so that he can gain weight since he was born early and only 5 pounds when he finally gain his weight he was switch to this new pro advance he does good and loves it but I came across with some bottles that had a really sour odd smell not like the ones purchased before and my baby was always vomiting so from know on I am always double checking the formula before giving to him since the stores don't do refunds.
Date published: 2017-02-14
Rated 2 out of 5 by from Fussy, gassy and constipated My baby was born 36 weeks after being on it for a month we've noticed throughout the month he would get fussy and gassy and spit up a little bit then started getting constipated and would be up all night.
Date published: 2017-02-10
Rated 5 out of 5 by from My baby loves this My baby loves this. And I like that ito natural.
Date published: 2017-02-10
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