Similac Pro-Advance™

Complete nutrition for baby’s first year, with added 2’-FL HMO prebiotic for immune support


Similac is the first infant formula brand with 2’-FL Human Milk Oligosaccharide* (HMO), an immune-nourishing prebiotic that circulates throughout the body. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant than ever before.


Moms reported a reduction in fussiness, gassiness, and crying after just one day of feeding.

2’-FL HMO facts:

  • Naturally abundant in most breast milk
  • Backed by more than 15 years of extensive research
  • Adds another layer to Similac’s already proven immune support

Similac is the first leading infant formula brand with no artificial growth hormones. Similac dairy ingredients come from cows that have not been treated with artificial growth hormones.

Similac Pro-Advance is non-GMO§ and has OptiGRO™ , our unique blend of DHA, Lutein, and Vitamin E, to help support your baby’s overall growth, and brain and eye development. Trust Similac Pro-Advance to provide a strong start for your baby’s developing immune system.

* Not from human milk.
After switching to Similac Pro-Advance.
No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
§ Ingredients not genetically engineered.

Moms Reported† a Reduction in Fussiness, Gassiness & Crying After Just 1 Day of Feeding †After Switching to Pro-Advance
Similac Pro-Advance™ Milk-Based Infant Formula Container

Available In:

Similac Pro Advance Formula Powder Can 30.8-oz Powder

Similac Pro-Advance™ Milk-Based Infant Formula Tub 1.41-lb Powder

1 QT Ready to Feed Similac Pro Advance Formula Bottle 1-qt Ready to Feed

Moms Reported† a Reduction in Fussiness, Gassiness & Crying After Just 1 Day of Feeding †After Switching to Pro-Advance

Nutrition Information

Powder / 1.41 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

1.41 lb. Similac Pro-Advance™ milk-based powder formula
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Similac Pro-Advance Reviews

Rated 5 out of 5 by from Best formula My baby spit up a lot!!! This formula is the best! I would recommend to anyone. The pro advanced is the one I use I would never go back or use another formula again!
Date published: 2018-07-09
Rated 5 out of 5 by from BEST alternative to breast feeding, maybe better. This product has taken the place of me breastfeeding because of some medications i take. My baby girl has had this Formula from day one of her being born and she’s 3 months now... she has NEVER thrown up and she’s doubled in weight. This formula has everything she needs to help her grow strong and healthy. I think it’s a fabulous product and would recommend it to all moms!!!
Date published: 2018-07-05
Rated 5 out of 5 by from Only brand for my son My son is 4 months old and unfortunately I could only breastfeed for 2 months. We tried multiple brands of formula, including the ones that are "comparable" to Similac. My son suffered with horrible constipation with every formula, including ones for constipation. After much trial and error, and reading many many formula labels, I found that Similac is the only brand that does not contain palm olein, which causes constipation in babies. I started using Similac Pro-Advance and magically his constipation resolved! Although it is pricier than the generic store brand ones, the cost is worth it to not have the constipation problems. The only complaint I do have is that I can't figure out how to get coupons from the company!
Date published: 2018-07-03
Rated 5 out of 5 by from The very best for our baby My daughter was born on 4/10/18. The hospital gave us a “newborn” milk. Which is fine, some kids do fabulous on it, I am sure. She started spitting up like mad, screaming, crying the whole gamut before we left the hospital even. And thus began this crazy rollercoaster ride. Pediatrician said: “milk allergy”. Neither my husband nor I believed it, but, really what the heck do we know? So they gave us Alimentum and sent us on our way. Alimentum helped, SOME, but... we knew something was wrong. Very, very wrong, Shortly after starting on Alimentum, my daughter started breathing weird, started screaming even more. Back to pediatrician, who referred us to a wonderful ENT. At the ENT she was diagnosed with Laryngomalacia and reflux. She was given medication, we were reassured that “yes” something WAS wrong, but that medication (Zantac at the time) would help with her reflux. Screaming, continued. Pediatrician put her on another formula that’s also hypoallergenic....and then? Diaper rash from out of this world. Back to pediatrician. He says “go to GI”. At this point? My then 7 week old is tired. I am tired. My 3 year old is asking why the baby is always angry and my husband? Well...he’s volunteering for overtime to escape the new baby. So..I secured a new script for an actual PPI, and started to question this “milk allergy” hypothesis. On a whim, and out of desperation? I tried this. Similac, I am thankful you make Alimentum for kids who TRULY need it. I am. And THANK you for your sensitive formula as it was necessary for my older child with mastocytosis, but....FROM the bottom of my heart? Thank you for your Pro-Advance formula. The crying stopped, the spitting up stopped, the diarrhea stopped. It all stopped. Some will argue that the PPI is what was the magic “cure”- and maybe it was. Maybe. I think it was the right combination of things, each playing an equally important part. She’s been on this a few weeks now. Born at a healthy 7lb8oz, lost some weight through this whole ordeal and is now 11lb9oz. For her? Huge! Thank you thank you thank you thank you! I would definitely recommend this to moms & dads needing something, anything to work. I have used Similac products for all 5 of my kids- never had the opportunity (lol) to actually NEED something..ANYTHING to work the way this has for our family. I cannot thank you enough!
Date published: 2018-07-01
Rated 5 out of 5 by from Awesome formula! Our little one wasn't doing well on a different brand of formula, so we decided to switch to Similac since that's what he was on in the hospital. He really seemed to enjoy the change! I love that this formula has prebiotics in it to help w/ digestion. His poops look great on this diet. His spit up/GERD issues have lessened and he is not getting hiccups as often. I love that this tub has the easy to use/find scoop holder on the lid. We're definitely Similac fans now!
Date published: 2018-06-29
Rated 2 out of 5 by from Daughter couldn’t use powder We had used premade from the time my daughter was born, we switched her to the powder to use our baby brezza and the powder made her super fussy and gsssy, she had a hard time pooping and caused her to spit up a ton. Back to premade we go!
Date published: 2018-06-24
Rated 1 out of 5 by from Very harsh on babies tummy My son was started on this in the hospital. He has been so gassy and fussy. Almost immediately he’s crying and screaming and it seems to run right through his system. It also has him waking up in the middle of the night screaming in pain. You can hear his poor tummy rumbling. I switched to pro sensitive and hopefully this works.
Date published: 2018-06-24
Rated 4 out of 5 by from Great on my 3 kids I loved it. My kids did amazing.
Date published: 2018-06-17
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