Similac Pro-Sensitive™*

Gentle nutrition for fussiness, gas, or mild spit-up, with added 2’-FL HMO prebiotic for immune support


Similac is the first infant formula brand with 2’-FL Human Milk Oligosaccharide (HMO), an immune-nourishing prebiotic that circulates throughout the body. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant’s than ever before.


2’-FL HMO facts:

  • Naturally abundant in most breast milk
  • Backed by more than 15 years of extensive research
  • Adds another layer to Similac’s already proven immune support

Similac is the first leading infant formula brand with no artificial growth hormones.§ Similac dairy ingredients come from cows that have not been treated with artificial growth hormones.

Similac Pro-Sensitive is non-GMO|| and has OptiGRO™, our unique blend of DHA, Lutein, and Vitamin E, to help support your baby’s overall growth, and brain and eye development. Trust Similac Pro-Sensitive to provide a strong start for your baby’s developing immune system.

* Not for infants or children with galactosemia.
Due to lactose sensitivity.
Not from human milk.
§ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
|| Ingredients not genetically engineered.

Similac Pro-Sensitive™ Milk-Based Infant Formula Container

Available In:

Similac Pro Sensitive Formula Powder Can 29.8-oz Powder

Similac Pro-Sensitive™ Milk-Based Infant Formula Tub 1.41-lb Powder

1 QT Ready to Feed Similac Pro Sensitive Formula Bottle 1-qt Ready to Feed

Nutrition Information

Powder / 1.41 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

1.41 lb. Similac Pro-Sensitive™ milk-based powder formula
Similac logo

New Moms

Join Similac® StrongMoms® Rewards for up to $400* in customized benefits, free gifts, and exclusive savings.
Strongmom Decor Dsk
SIGN UP * Offers may vary.

Similac Pro-Sensitive Reviews

Rated 4 out of 5 by from Fussiness Great product! We went through 3 formulas before finally settling on this one! I noticed much difference!
Date published: 2018-07-06
Rated 5 out of 5 by from No fussiness, no spitting up, no unhappy baby with tummy ache!! We love love this formula!! Happy baby makes very happy home!!
Date published: 2018-07-06
Rated 5 out of 5 by from Saw improvement in less then a day! My newborn was spitting up a lot including having large wet burps. Similac Sensitive reduces her spit ups to MAYBE one a day and hardly any wet burps. She isn’t fussy afterwards either!
Date published: 2018-07-05
Rated 5 out of 5 by from Such a Difference in just 2 Days!!! No more Soy! We had our 2 month old on a soy formula but our pediatrician recommended Similac Pro Sensitive for her lactose sensitivity... it has only been two days and she is so much more bubbly and happy. She is not as gassy and she isn’t spitting up as much either! I would recommend this formula to anyone instead of a soy formula!
Date published: 2018-06-30
Rated 5 out of 5 by from Great for fussy babies! Our little one wasn't doing well on a different brand of formula, so we used this one to help settle his stomach down while we transitioned to his new formula. This powder mixes super easily. The only complaint is that it foams/bubbles up quite a bit when mixed. But as long as you let the formula settle a bit prior to feeding we didn't encounter any issues. He had minimal spit up and almost no hiccups while on this. I'd even recommend having it on hand for in case of fussy baby.
Date published: 2018-06-29
Rated 2 out of 5 by from Doesnt work for mu son "as yet" My son is 36 days old and i switched to this brand because he is fussy, spits up alot and is still gassy.. I ve tried everything and nothing seems to work. However, I am going to stick with it for awhile and see if he improves. If not I will switch again to another brand and see if it works..
Date published: 2018-06-29
Rated 5 out of 5 by from It doesn’t smell like the formula I remember!!!! So easy to prepare and my grandson has done excellent on it. He’s 11 weeks old and growing perfectly. Haven’t had any problems with gas and hardly ever spits any up. Excellent!!!!
Date published: 2018-06-29
Rated 5 out of 5 by from Best formula for fussy babies This is the only formula my son can drink without getting very gassy. We have tried many different formulas and this is by far the best for a sensitive tummy.
Date published: 2018-06-29
Rated 5 out of 5 by from Works amaIng My newborn was gassy and cranky. Switched to this formula and within a couple of days it cleared right up :)
Date published: 2018-06-28
Rated 3 out of 5 by from It's ok At the hospital they gave my daughter Similac advance so when I came home I continued. However, she barely slept and was very colicy from the start. I used it for a few weeks to supplement breastfeeding but nothing I did worked. When she was on formula exclusively things got worse. We switched to similac sensitive and it helped. She is much better than before, however she still spits up a lot and is fussy.
Date published: 2018-06-28
Rated 4 out of 5 by from Good Switched to this when our baby started having watery diarrhea from pro advance. Only complaint is the amount of bubbles that form in bottle. I've tried shaking, swirling, stirring with a fork or spoon... no matter what there is always an ounce wasted because of the amount of bubbles that form.
Date published: 2018-06-26
Rated 5 out of 5 by from Awesome ! The best formula by far that keeps my baby's tummy and bowels regular! Plus great for fussiness :) happy mom
Date published: 2018-06-25
Rated 5 out of 5 by from This worked wonders for my daughter This was amazing. My daughter was gay abbe fussy abbe this formula was the only thing that helped her tummy
Date published: 2018-06-22
Rated 3 out of 5 by from Foamy My baby has some gas issues and I thought this formula would help. This formula is SO foamy I feel like it made his tummy it suppose to be foamy?
Date published: 2018-06-19
Rated 3 out of 5 by from It worked My baby was having problems with gas and colics. They switched the formula to this one and it worked
Date published: 2018-06-19
Rated 4 out of 5 by from Less spit up and gas! When my daughter was born I breast fed her for the first two months and supplemented with enfamil spit up formula but that didn’t seem to help with her spit up. At her 3 month appointment her pediatrician recommended the similac pro sensitive! At that time I switched over from breast feeding to straight formula. I have noticed she is not spitting up as much as she was before! She spits up some times but most of the times she keeps it down! She is sleeping through the night better now because she isn’t as gassy and she doesn’t spit up as much. I’m satisfied with this product!
Date published: 2018-06-19
Rated 5 out of 5 by from This product has helped my baby with digestion My baby loved this cersion of Similac, and has had big improvement with digestion, after the first few days of using it.
Date published: 2018-06-16
Rated 1 out of 5 by from Awful Tummy Pain I bought my baby this because he was having a little gas which was making him fussy. The formula is extremely frothy so when he's eating he gets a lot of air. It made his gas worse! Not only is the gas worse but now he's spitting up which he's never done before. My poor baby wakes up crying in pain. I can HEAR his stomach rumbling. To pass gas or poop he has to strain and cries every time he needs to. This may work for some babies but definitely not mine. Ill be switching to something different. I can't stand seeing him in pain :(
Date published: 2018-06-16
Rated 5 out of 5 by from Helps reduce gas Foamy, but has helped improve gas in my baby. We are also using gas drops to help. Using the gas drops in the milk reduces the foam.
Date published: 2018-06-15
Rated 2 out of 5 by from Foamy and increased spit up We switched from Similac Advanced to Similac sensitive since my baby was in discomfort after feedings. We noticed a difference and it really helped our baby. We then realized that Costco only sold the Similac Pro-Sensitive and after reviewing the ingredients, it seemed to be almost identical so we switched. Not the case! After using the pro-sensitive, my baby had increased spit up after every feeding. It also had more foam than the regular sensitive. I would recommend sticking with the Similac sensitive and not try the Pro-Sensitive.
Date published: 2018-06-14
Rated 4 out of 5 by from Reduces spit ups It worked pretty well to reduce spit ups, my baby likes similac products taste very much
Date published: 2018-06-10
Rated 1 out of 5 by from Foam and Constipation I thought I was doing good for my baby switching from the advanced to sensitive because of her gas but I was completely wrong. When we first mixed it up I thought I may not have washed all the soap out of the bottle because the amount of foam! I let it sit to try to get it to go down but it never got any better. Day one and two wasn’t terrible, although her gas didn’t improve. It was day three when her poop started to turn harder and she would cry every time she ate while straining. She also wasn’t eating as much with each feeding. I used similac sensitive with my oldest almost four years ago and never had any of these issues. Not sure if it’s the new “pro” part of it but I wouldn’t recommend this or give it to my baby again. Just hoping I can return all the sensitive formula I bought and get the advanced. If she doesn’t do well on the advanced then it looks like we will be switching to enfamil.
Date published: 2018-06-10
Rated 5 out of 5 by from Good enough for both Our daughter was put on Similac Pro-Sensitive at the hospital after we were asked what formula our son had been on when he was born. Just like our experience with our son, our daughter has not had any problems with this formula. For both of my kids, the lack of tummy troubles has been amazing!
Date published: 2018-06-08
Rated 3 out of 5 by from Foamy Recently I’ve switched my daughter to this from similac neosure though her dr really wants to keep her on neosure due to her being a preemie and gaining good weight from it. It upsets her stomach really bad. Switched to this 2 days ago and formula is very foamy unsure if this will cause her more discomfort still trying to test it out. Really hope this work. I wish there was a sensitive formula for preemies though as the preemie formula has the extra benefits that she needs.
Date published: 2018-06-04
Rated 1 out of 5 by from Horrible discomfort My daughter was ready to start transitioning from breast milk and this product was recommended. WORST, suggestion ever!! Almost immediately my daughter was gassed up, bloated, irritable and hysterical. She wasn’t able to pass gas or stools. She woke up screaming in pain every night. There is nothing SENSITIVE about this product.
Date published: 2018-06-04
Rated 5 out of 5 by from Very good easy transition from breastmilk My little one is now 7 months, he was exclusively breast fed up to 4 1/2 months but after an unexpected event in our family I was not able to breast feed him for a couple of days so so we gave him formula. We tried couple different formulas, I had sample size but he would spit up all of them except with this one. I've gone back to breastfeeding but he does get a bottle here and there especially since he gets an upset stomach whenever I have dairy. This is a life saver, I would defenetly recommend it.
Date published: 2018-05-30
Rated 4 out of 5 by from Still waiting to see... So far babe has been much better on this than an organic formula for sensitive tummies that gave him gas pains and caused constipation. It has been less than a week since we switched and his bowel movements are regular with no added juice to his bottles. He also passes gas without pain. My husband has tasted both breast milk and this formula and gives positive feedback on taste as well. I refuse to taste them as it freaks me out!!! I’m not giving 5 stars because I need to see the more long-term effects first but so far so good! Grateful for this product!
Date published: 2018-05-28
Rated 5 out of 5 by from Compared to others. My daughter tolerated this one better than others and seems to like it.
Date published: 2018-05-25
Rated 4 out of 5 by from Great product My daughter responds well to this product ...keeps it down and seems to like it
Date published: 2018-05-24
Rated 5 out of 5 by from Love it This formula works best for my baby. It’s a little pricey but they send coupons so it works. I tried to switch but always end up back with this one.
Date published: 2018-05-22
  • y_2018, m_7, d_16, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.8
  • cp_2, bvpage2n
  • co_hasreviews, tv_0, tr_604
  • loc_en_US, sid_sim-prod-710, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING), SortEntry(order=FEATURED, direction=DESCENDING)]
  • clientName_similac
  • bvseo_sdk, net_sdk,
  • CLOUD, getReviews, 78ms