Similac® NeoSure®

Promotes catch-up growth during your premature baby’s first 12 months


Your premature baby didn’t get her full 9 months in the womb, so her body is working hard to catch up.

Help support her development in the first full year by feeding her Similac NeoSure, a nutrient-enriched* formula for babies who were born prematurely.


Supports excellent growth during baby’s first year.1

  • Increased protein, energy, vitamins, and minerals compared to term infant formula
  • Extra calories for growth
  • Calcium and phosphorus for baby’s growing bones

Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula.1 Has OptiGRO to support your baby's brain and eye development.

Learn more about the nutritional needs of your preemie.

Get tips for keeping your baby’s immune system strong.

Learn why catch-up growth is important.

* Increased protein, vitamins, and minerals compared to term infant formula.
Reference: 1. Carver JD, et al. Pediatrics. 2001;107:638-689.

Similac NeoSure 13.1 oz formula with Iron for preemies

Available In:

Similac NeoSure 13.1 oz formula with Iron for preemies 13.1-oz Powder

Similac NeoSure 13.1 oz formula with Iron for preemies 1-qt Ready to Feed

Similac NeoSure 13.1 oz formula with Iron for preemies 2-fl-oz Ready to Feed

For babies who were born prematurely

Nutrition Information

Powder / 13.1 oz

Serving size: 100 Cal (4.5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac NeoSure
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Similac NeoSure Reviews

Rated 1 out of 5 by from Constipated Twins I pretty much have the same problem as shelbiwelbi. My twins were born March 3rd at 32 weeks. While they were in the NICU, they were taking the Ready to Feed bottles. When they were discharged 13 days later, we were sent home with a couple days worth of the bottles as well. Both boys were having regular bowel movements a couple times a day but about a day or two after switching to the powder I noticed that they both were constipated. Immediately after they eat, they grunt and strain to produce a bowel movement that sometimes never happens. At some point of the day, if a bowel movement finally happens, they resemble rabbit pellets or a hard ball. (SORRY IF THAT'S TOO MUCH INFO) Like the previous poster stated, this too breaks my heart and makes me want to cry when I see the pain in their faces from the issues they are having. I came to this site to gather some info before switching the formula. My suspicion seemed to be confirmed and I also see that my babies aren't the only ones having this problem.
Date published: 2018-03-31
Rated 1 out of 5 by from Constipated my daughter severely My daughter was born at 34 (almost 35) weeks and was in the NICU for 2 weeks. While she was there she was given the ready made bottles of this formula to supplement for breast milk. Thankfully I was producing a good amount of milk and for the most part she didn’t even have to drink the formula, but even before she was drinking 100% breast milk she was never constipated, gassy, or fussy. The NICU sent us home with a can of the Neosure and her pediatrician gave us 3 cans as well when she found out my milk supply started to decrease. At about 5 weeks I had to start supplementing with formula and I noticed an immidiate change. My daughter (who normally pooped after every feeding, every 3 hours) was pooping once a day, and she struggled all day because she was constipated. She was in so much pain, it made me want to cry. I did my research on the internet and found out that several other parents complained about the same problem. I’ve also read that this formula helps premie babies gain weight, which is great, but my daughter had no problem gaining weight before the formula. But I’m not sure the payoff is worth the pain. The only good thing I have to say about the formula is it helped my daughter sleep longer.
Date published: 2018-03-30
Rated 3 out of 5 by from Good but causes gas issues My twins are using neosure after being discharged from the nicu. I noticed they were fine while using the formula in the nicu but experienced constipation and bad gas when at home. I'm assuming this is due to the powder versus ready to feed. What is the difference in the formula blend that would make the ready to feed easier to digest?
Date published: 2018-03-26
Rated 1 out of 5 by from This product causes severe gas My son was born premature at 33 weeks. During his time in NICU he was given the ready made Neosure. We continued with neosure once we were released but switched to powder due to cost. I'm assuming its the same product, however, my son has severe gas pains after each feeding. He turns red, grunts, pushes, high cries to release a small air from his bottom. I know babies can have normal gas, but this is not normal. Peditrician does not want to change formula yet and waiting to see at his next apt. One positive my son has gained weight BUT at what cost- its painful to see him struggle with gas.
Date published: 2018-03-20
Rated 2 out of 5 by from Gassy , projectile vomiting and constipation Oh My! Preemie twins born at 34 weeks and Nicu gave Neosure. They have had Neosure till now at 4 months old. Both have gained weight and seem healthy. BUT....they have gone thru many periods of painful gas, straining from constipation, projectile vomiting and overall crankiness and crying after a Neosure feeding. Not happy with the side effects and their doctor won't suggest an alternative.
Date published: 2018-03-15
Rated 4 out of 5 by from Love it - wish you would have the 8oz ready to feed This has worked great for our son and his weight gain. Just wish you had the 8oz ready to feed bottles, or even the pre-measured on the go packets. Those would come in handy for travel and being out an about.
Date published: 2018-03-04
Rated 5 out of 5 by from Great for gaining weight I had my twins @ 25 weeks they been drinking neosure since day one and their weight has picked up tremendously plus their motor and fine motor skills are all up to date and then some i have nothing good but good things to say about neosure the price is even affordable, the only thing i cannot find in the similac website is a recipe to change 22cal/oz into 28cal/oz ????????
Date published: 2018-02-25
Rated 3 out of 5 by from does the job but pricey and with lots of gas I was told my preemie (born 33 weeks, now 2 months old) needed this formula for the nutritional benefits so I felt I had no real choice but to do it for her health. She is gaining weight beautifully so that's a win, however her gas is REALLY bad with this formula and every feed is crying, cramping gas pains. She's burping ok and I've switched bottles 2 weeks ago to non-colic bottles but there's no help, which only leads me to believe this formula is upsetting her belly. The price is also so so high its a burden on our budget big time.
Date published: 2018-02-23
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