Similac® NeoSure®

Promotes catch-up growth during your premature baby’s first 12 months


Your premature baby didn’t get her full 9 months in the womb, so her body is working hard to catch up.

Help support her development in the first full year by feeding her Similac NeoSure, a nutrient-enriched* formula for babies who were born prematurely.


Supports excellent growth during baby’s first year.1

  • Increased protein, energy, vitamins, and minerals compared to term infant formula
  • Extra calories for growth
  • Calcium and phosphorus for baby’s growing bones

Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula.1 Has OptiGRO to support your baby's brain and eye development.

Learn more about the nutritional needs of your preemie.

Get tips for keeping your baby’s immune system strong.

Learn why catch-up growth is important.

* Increased protein, vitamins, and minerals compared to term infant formula.
Reference: 1. Carver JD, et al. Pediatrics. 2001;107:638-689.

Similac NeoSure 13.1 oz formula with Iron for preemies

Available In:

13.1-oz Powder

1-qt Ready to Feed

2-fl-oz Ready to Feed

For babies who were born prematurely

Nutrition Information

Powder / 13.1 oz

Serving size: 100 Cal (4.5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac NeoSure
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Similac NeoSure Reviews

Rated 4 out of 5 by from My babies are doing great on the Neosure I have seen a few negative reviews on here so I figured I'd share my experience. This product is not perfect, but it works. My twins were born at 35 weeks have always been on Neosure. Admittedly, they had less digestion issues with breast milk, but breast milk wasn't an option for us for very long. My babies were both tiny so they needed to gain weight fast to stay healthy and graduate from the NICU. Neosure got the job done. At two months my kids are happy and healthy 8 pounders thanks to Neosure, so I am happy with it. Maybe there is room for improvement but I am just grateful it was an option for us.
Date published: 2018-12-15
Rated 4 out of 5 by from Great product, low supply, high price tag I gave birth to two 2-pound premies 11 years apart, and both thrived on Neosure. Lately, I’ve been finding it so hard to get it at the stores as they only have 1 or two at the shelves at a time. Also, the high price tag of Neosure with all the other expenses added to having a premie surely hits hard. Other than that, I’m happy there’s a formula meant for babies like mine.
Date published: 2018-12-09
Rated 4 out of 5 by from I appreciate this product but have a suggestion I am the mother of a preemie born at 34.5 weeks. This product is a great one produces little to no excess gas, stores conveniently and always fresh however i have a suggestion. Im not sure whose idea it was to make the scope inside the container the same size as the opening of the bottle. When preparing the powdered formula there is always waste outside the bottle which allows for inaccurate preparation and measurement. Perhaps if the scoop was deeper and more narrow allowing for better preparation I would have rated this product a perfect 5. I love that Similac has always been a product that a parent could rely on however its the small things that make consumers appreciate a product.
Date published: 2018-12-02
Rated 3 out of 5 by from Great formula but VERY expensive! My twin grandbabies have been on this formula since their premature birth and will continue for another 2 months minimum. They have gained a good bit of weight and we couldn't be happier. Both have dealt with some gas and constipation from this formula. However, not only is Neosure difficult to find in stores it is also VERY expensive especially when purchasing for twins. Like many other preemies, the Twins spent time in the NICU which created unbelievable medical bills. It would be nice if Similac would take into consideration Neosure is primarily for preemies and parents have already been hit with lots of expenses. The parents have made the sacrifices to continue to purchase this formula for the Twins because that is what is best.
Date published: 2018-11-29
Rated 5 out of 5 by from Good and expensive My baby born 36 week weight 4lb 9oz, in three months he weight 12lbs by now. When he was in the NICU , they bottle feed him on Similac Pro-Advance which carry 19 calories so his doctor prescribe the neosure which carry 22 calories. His doctor he going to fatten my baby up so sudden say and done. Only thing is purchasing the formula even through I get assistance but they give so little plus breastfeed 50% of the time. In the first 2 months my baby was going through gassy, constipation using the neosure product. I end up using the baby purified water with the formula with proper sterile bottle; no more constipation but a lot of passing gas.
Date published: 2018-11-21
Rated 5 out of 5 by from This formula really help my premature baby Like a lot of parents experience, while my baby was in the NICU he did great with neosure formula but once I got hope and started preparing the powder formula my baby started being gassy, fussy and even seem contipated even when I was still breastfeeding 75% of the time. I began looking online to see if others had the same problem. I realized that I was using the wrong water. The formula already has minerals and by using water specific for babies that already had minerals it was too much for my baby. I use regular distilled water and my baby is doing great. He is now on only formula and he is no longer gassy or constipated. He is 5 months now. Believe me I wanted to switch the formula plenty of times because my baby was in so much pain but now I’m glad I did. Please give it a try, change the water your using it might make a huge difference.
Date published: 2018-11-20
Rated 4 out of 5 by from Doing well My granddaughter was not premature but very tiny due to placental issues. She has done very well on this product. It is difficult to find. The price seems about the he same as other formulas. There are two stores in my town that it is significantly less expensive. It would be nice to be able to have a larger can! Also my daughter signed up for this site but has never received a coupon of any kind. Why are you taking people’s information?
Date published: 2018-10-31
Rated 3 out of 5 by from Average product For the price and lack of availability, I am hoping for the best for my beloved premie. Unfortunately I agree with many that it causes excessive gas & discomfort & makes my baby unhappy. He has been through so much already at the nicu and I was hoping things would get better. I am strongly thinking of switching to a different formula which is a shame since my first one relied heavily on Similac. We are loyal customers but not a fan of neosure!
Date published: 2018-10-26
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