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Similac® NeoSure®

Promotes catch-up growth during your premature baby’s first 12 months


Your premature baby didn’t get her full 9 months in the womb, so her body is working hard to catch up.

Help support her development in the first full year by feeding her Similac NeoSure, a nutrient-enriched* formula for babies who were born prematurely.


Supports excellent growth during baby’s first year.1

  • Increased protein, energy, vitamins, and minerals compared to term infant formula
  • Extra calories for growth
  • Calcium and phosphorus for baby’s growing bones

Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula.1 Has OptiGRO to support your baby's brain and eye development.

Learn more about the nutritional needs of your preemie.

Get tips for keeping your baby’s immune system strong.

Learn why catch-up growth is important.

* Increased protein, vitamins, and minerals compared to term infant formula.
Reference: 1. Carver JD, et al. Pediatrics. 2001;107:638-689.

Similac NeoSure 13.1 oz formula with Iron for preemies

Available In:

13.1-oz Powder

1-qt Ready to Feed

2-fl-oz Ready to Feed

For babies who were born prematurely

Nutrition Information

Powder / 13.1 oz

Serving size: 100 Cal (4.5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac NeoSure
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Similac NeoSure Reviews

Rated 2 out of 5 by from So expensive and causes constipation/gas pains My preemie was born at 35 weeks and this is the formula my ped recommended we used at home. I’m not sure how anyone can afford to buy this weekly and then have preemie medical bills ontop of it. Something needs to be made that’s affordable and does the same job for our little ones. Crazy :( Also my baby squirms in pain every time he eats. Along with arching his back and grunting this formula gives him constipation and ALOT of gas. I feel so bad.
Date published: 2018-09-19
Rated 3 out of 5 by from Product has been great for my baby but SOOO EXPENSIVE My baby was born at 35 weeks, but stopped growing at about week 31. He was 3lbs 10oz. The NICU sent us home with neosure, and the pediatrician recommended that he stay on it. He is about to rub out again. It's going to break the bank. There should be something out there for premie babies that doesn't break the bank.
Date published: 2018-09-14
Rated 4 out of 5 by from Good but expensive My son was born 5 weeks early to due my having ore-eclampsia. This is the formula that the nicu and his pediatrician are telling me to use, and I want to continue to. It has helped him gain weight and it's easy to make. However, it is one of the more expensive ones and we have a lot of expenses what with me and him being hospitalized for 50 days. I wish it wasn't so pricey. 1-2 cans a week is almost $100 a month- a big expense.
Date published: 2018-08-15
Rated 3 out of 5 by from Great for weight gain but causes constipation My preemie was born at 33 weeks and the NICU supplemented with the Neosure. It's done wonders for his growth but has caused so much gas and constipation.
Date published: 2018-08-04
Rated 3 out of 5 by from Great but tiny can This is a great product but it does cause our baby to be pretty gassy and constipated. I do not really like that it’s in such a tiny can because it’s pretty dang expensive!
Date published: 2018-08-02
Rated 4 out of 5 by from Love it! Just wish it was a little more affordable. Our little guy was born at 29wks 5days. He spent 3 months in the NICU and was started on Neosure there. He did get a bit gassy when he came home, but nothing some over the counter (pediatrician approved) gas drops, & tummy massages couldn't handle. He only had a couple of doses before his stomach adjusted to the volume, and of course bottle feeding itself, as he had been fed through a feeding tube for the majority of his NICU stay. Weight gain was never a concern with him, and I believe a large part of that was due to this formula, & an abundance of prayer of course! The only downside, and reason I gave it 4 stars, has nothing to do with the quality of this product, but with the cost. Each can is almost $20.00, and now that he's going on 9mo (6mo adjusted) he goes through 2 and a half cans a week. We don't qualify for any sort of financial assistance so on top of our new homes mortgage (purchased just before finding out I was prego), hospital bills, daycare, and life in general, it's getting pretty difficult to keep up with little man's appetite. All in all, I would still whole heartedly recommend this product for preemie babies!
Date published: 2018-07-16
Rated 3 out of 5 by from Constipated and Gassy This formula both ready to feed and powder made my 36week premie extremely gassy and constipated of course the NICU was feeding him this and he did fine in the hospital with an IV but once we got home his bowel movements have been maybe once a day if that. I can tell he’s hydrated because he’s peeing a lot and it’s a light in color. But he has been extremely unconfortable since being home with how gassy and consitpated he has been. With being a new single mother it has been very tough for me to comfort him when he has his rough days. We will be consulting with his pediatrician about another formula that will be better for him. Originally he was started on Similac because that’s what WIC here prefers, but I’d rather pay more out of pocket and have my baby comfortable without the headache.
Date published: 2018-07-07
Rated 4 out of 5 by from Great for preemies but with some caveats. Our twins were born at 34 weeks so they have been on NeoSure since the get go. It has helped them tremendously. However, now that we are a few months old and still on it, we have noticed the following: - NeoSure makes our preemies constipated with less bowel movements than with breastmilk - NeoSure makes them EXTREMELY gassy which creates fuzzy nights - NeoSure cans are so tiny and our twins go through so many of them that it’s a hassle. These bottles are $20 each and we go through a can every day and a half so imagine the huge expenditure. I wish NeoSure would listen to the consumers and make some fixes to their product. Apart from that, this is great for our preemies.
Date published: 2018-06-28
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Has your family been affected by Hurricane Florence?

If you or someone you know has been affected, find out how Similac® can help.