Similac® NeoSure®

Promotes catch-up growth during your premature baby’s first 12 months


Your premature baby didn’t get her full 9 months in the womb, so her body is working hard to catch up.

Help support her development in the first full year by feeding her Similac NeoSure, a nutrient-enriched* formula for babies who were born prematurely.


Supports excellent growth during baby’s first year.1

  • Increased protein, energy, vitamins, and minerals compared to term infant formula
  • Extra calories for growth
  • Calcium and phosphorus for baby’s growing bones

Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula.1 Has OptiGRO to support your baby's brain and eye development.

Learn more about the nutritional needs of your preemie.

Get tips for keeping your baby’s immune system strong.

Learn why catch-up growth is important.

* Increased protein, vitamins, and minerals compared to term infant formula.
Reference: 1. Carver JD, et al. Pediatrics. 2001;107:638-689.

Similac NeoSure 13.1 oz formula with Iron for preemies

Available In:

13.1-oz Powder

1-qt Ready to Feed

2-fl-oz Ready to Feed

For babies who were born prematurely

Nutrition Information

Powder / 13.1 oz

Serving size: 100 Cal (4.5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac NeoSure
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Similac NeoSure Reviews

Rated 4 out of 5 by from Doing well My granddaughter was not premature but very tiny due to placental issues. She has done very well on this product. It is difficult to find. The price seems about the he same as other formulas. There are two stores in my town that it is significantly less expensive. It would be nice to be able to have a larger can! Also my daughter signed up for this site but has never received a coupon of any kind. Why are you taking people’s information?
Date published: 2018-10-31
Rated 3 out of 5 by from Average product For the price and lack of availability, I am hoping for the best for my beloved premie. Unfortunately I agree with many that it causes excessive gas & discomfort & makes my baby unhappy. He has been through so much already at the nicu and I was hoping things would get better. I am strongly thinking of switching to a different formula which is a shame since my first one relied heavily on Similac. We are loyal customers but not a fan of neosure!
Date published: 2018-10-26
Rated 5 out of 5 by from Great formula for preemies I just recently had twin boys at 35 weeks. Since they were preemie they recommended Neosure so we have been on it for the past 4 weeks. We have had several appointments with our pediatrician for weight checks and finally today we made progress... Our pediatrician said he would give us samples if he had some but their current rep doesn’t come and provide many samples. We are happy with the product and don’t want to switch to Enfamil because we like Similac products but with two baby’s eating every 3 hours it’s hard to pay $20 for a tiny can every 2-3 days... I’m hoping to find a solution so my boys can keep enjoying their formula and get those calories!!! We love Similac!
Date published: 2018-10-26
Rated 3 out of 5 by from Expensive My baby was born at 34 weeks and the NICU put her on Neosure and her pediatrician wants to keep her on it for a while to gain weight. Im now a stay at home mom and i wish there was an option for assistance paying for the formula, we go through about 6 cans a month.
Date published: 2018-10-25
Rated 4 out of 5 by from Good for premies but really expensive Our NICU doctors suggested that we continue on the same brand "neosure" once the babies are discharged. Though the babies are gaining weight our boy has gas issues. Also this product is really expensive. I am a stay at home mom. With just one income we seriously wonder how long can we afford this. Product definitely works for premies to gain weight. I really recommend.
Date published: 2018-10-17
Rated 2 out of 5 by from Expensive My grandson was born at 29 weeks, momma had preeclampsia. She tried nursing, didn't work, baby was put on Neosure. This stuff is very expensive and does seem to cause gas. It's hard for the parents to buy this because it is so expensive. I feel like we are all being taken advantage of because of the special needs for our preemies. And yes, I know it has all of the vitamins and nutrients but does it have to cost an arm and a leg? I say shame on you Similac.
Date published: 2018-10-15
Rated 3 out of 5 by from This product is helpful but at the expense of a gassy uncomfortabe baby My baby was born at 34 weeks weighing 3lbs 11oz. He stayed in NICU 12 days and was immediately put on Neosure 22 for weight gain while also supplementing with breast milk. During the first month our baby was taking Neosure just fine but by month 2 is when we noticed fewer poops, more spit up and extreme gassiness. Although we were advised to give two servings of Neosure daily while also taking breast milk our baby seem to develop an intolerance for Neosure. Our Pediatrician suggested we give baby half and half meaning 1/2 Neosure and 1/2 Pro- Advance. We had least spit ups and he still gained but did not poop often. We just purchased Total Comfort and I am looking forward to seeing some relief for our baby based on all the reviews about Total Comfort.
Date published: 2018-10-02
Rated 2 out of 5 by from Few problems Everything was fine until my baby made 2 months I noticed she get extremely constipated after drinking neosure. She cries & fusses .. I asked the doctor what can I do they told me try apple juice, it helps a little but not much . I hate that she have to go through this everyday
Date published: 2018-09-27
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