Similac® NeoSure®

Promotes catch-up growth during your premature baby’s first 12 months


Your premature baby didn’t get her full 9 months in the womb, so her body is working hard to catch up.

Help support her development in the first full year by feeding her Similac NeoSure, a nutrient-enriched* formula for babies who were born prematurely.


Supports excellent growth during baby’s first year.1

  • Increased protein, energy, vitamins, and minerals compared to term infant formula
  • Extra calories for growth
  • Calcium and phosphorus for baby’s growing bones

Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula.1 Has OptiGRO to support your baby's brain and eye development.

Learn more about the nutritional needs of your preemie.

Get tips for keeping your baby’s immune system strong.

Learn why catch-up growth is important.

* Increased protein, vitamins, and minerals compared to term infant formula.
Reference: 1. Carver JD, et al. Pediatrics. 2001;107:638-689.

Similac NeoSure 13.1 oz formula with Iron for preemies

Available In:

Similac NeoSure 13.1 oz formula with Iron for preemies 13.1-oz Powder

Similac NeoSure 13.1 oz formula with Iron for preemies 1-qt Ready to Feed

Similac NeoSure 13.1 oz formula with Iron for preemies 2-fl-oz Ready to Feed

Nutrition Information

Powder / 13.1 oz

Serving size: 100 Cal (4.5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac NeoSure
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Rated 3 out of 5 by from Too costly As good as this stuff may be, for those of us just over the income limits for WIC this product is not very affordable. I have an infant who was born at 24 weeks but even with a few coupons that I find, etc. this formula really socks it to you on the price. I wcan she it was more affordable especially for the size cans it’s available in. Good for preemies, bad on ththe pocketbook.
Date published: 2018-02-19
Rated 3 out of 5 by from Bad gas and hard to find! My son was born at 34 weeks and I have been fortifying my breastmilk with neosure since he was about 1 week old. He has been gaining weight fine but, he is constantly grunting/pushing/arching his back to pass gas and it smells rancid! He has finally gotten to the point where he will eat about 1oz and has trouble eating anymore because he is grunting and pushing so hard to pass gas. He has also been getting increasingly fussy and will vomit his entire feeding shortly after eating. I had a sample can of pro-sensitive and switched him to that this morning. I swear I am feeding a different kid! Way better! Neosure is also really hard to find for that I wish the cans were bigger. Most Walmart’s have it but it is usually sold out. Occasionally I will find it at Target but some don’t even carry it.
Date published: 2018-02-12
Rated 3 out of 5 by from Gassy, No Bowel Movement for Days This formula is doing me and my little one no good. My baby stains so hard that she turns red. She hasn't had a bowel movement in days. I didn't have a problem with the ready feed bottles we received when we got discharged from the hospital. Luckily I am enrolled in the WIC program.Something needs to be done about this formula from all the other reviews basically saying the same thing.
Date published: 2018-02-12
Rated 1 out of 5 by from My daughter is suffering! She was born at 33 weeks and currently she’s 6 weeks old. I don’t like this formula! It makes her fussy, gassy and constipated! Something has got to give! It’s a shame a vast majority of people that have complained have the same complaints. Y’all have to do something these babies are suffering.
Date published: 2018-02-10
Rated 5 out of 5 by from It's been excellent for our daughter Our daughter has been with neosure since day one and we have had excellent doctors visits. She is developing nicely and has surpassed so many goals that were set for her. We are very happy with this product and recommend it highly!
Date published: 2018-02-10
Rated 2 out of 5 by from Gassy/Fussy and Hard to Find! My little one was born at 34 weeks and has had difficulty with weight gain. The pediatrician recommended staying on this for at least 6 months. We have been struggling to not only PAY for the formula but also FIND the formula. I have bought out the few cans our stores seem to have but I am not traveling all over the greater Chicago area to find formula. The other concerning issues is that my little lady has been gassy, uncomfortable and irritable on this formula however, needs the calories. She is so uncomfortable that she does not sleep through the night nor is she comfortable enough to sleep/nap which is affecting her growth as well. It's probably a great product but in our case it is a daunting product.
Date published: 2018-02-07
Rated 1 out of 5 by from Causes Gas, Diarrhea and Vomiting! Our little man was born at 31 weeks. When we were discharged from the NICU we were informed that we would be giving our son two bottles of Neosure every day to ensure his growth. Ever since we started giving him the Neosure our little angel has turned into a fussy, gassy little man that no longer sleeps between feeds and diaper changes. He tosses and turns in the night in pain and has been so gassy. His healthy poops have turned into a black soupy mess. On two different occasions in a 4 day period he has projectile vomited the formula. I don’t see how these awful chemicals are going to help him grow and this is turning my life into a nightmare!
Date published: 2018-02-07
Rated 3 out of 5 by from Super Expensive & Gassy to boot! Hi there. My daughter was born at 33 weeks and in the NICU they gave her Similac Advanced in the 2oz ready-to-feed bottles. She seemed to do well with that while in the hospital but I was unable to find it once discharged. Then the pediatrician switched us to an Enfamil formula and after I had purchased, she changed it again. Now I have all of this formula and cannot return it. Currently we are on Similac Neosure in order to assist with weight gain. Unfortunately I just purchased the Similac Advanced, The Enfamil Gentle-Ease, and now the Similac Neosure and not only has this been SUPER expensive, but now my daughter is fussy and gassy! After she eats 1 ounce I burp her, hoping to combat the gassiness that will surely come later. That has not worked. She strains and cries, arches her back, doesn't have a bowel movement for days on end and constantly passes gas. I bought her some Tummy Calm per a recommendation and am hoping it will help with this. However, it definitely will not help the strain of my pocket book! Is there a program where I can swap my formula? Or a coupon I might be able to apply for? With all these different formulas I'm afraid I won't be able to afford another formula switch :-(
Date published: 2018-01-20
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