Similac® NeoSure®

Promotes catch-up growth during your premature baby’s first 12 months


Your premature baby didn’t get her full 9 months in the womb, so her body is working hard to catch up.

Help support her development in the first full year by feeding her Similac NeoSure, a nutrient-enriched* formula for babies who were born prematurely.


Supports excellent growth during baby’s first year.1

  • Increased protein, energy, vitamins, and minerals compared to term infant formula
  • Extra calories for growth
  • Calcium and phosphorus for baby’s growing bones

Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula.1 Has OptiGRO to support your baby's brain and eye development.

Learn more about the nutritional needs of your preemie.

Get tips for keeping your baby’s immune system strong.

Learn why catch-up growth is important.

* Increased protein, vitamins, and minerals compared to term infant formula.
Reference: 1. Carver JD, et al. Pediatrics. 2001;107:638-689.

Similac NeoSure 13.1 oz formula with Iron for preemies

Available In:

13.1-oz Powder

1-qt Ready to Feed

2-fl-oz Ready to Feed

For babies who were born prematurely

Nutrition Information

Powder / 13.1 oz

Serving size: 100 Cal (4.5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac NeoSure
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Similac NeoSure Reviews

Rated 4 out of 5 by from Helped Preemie gain weight but terrible ga and constipation Our little one (LO) was 6 weeks early and spent a few weeks in the NICU. Our pediatrician gave us orders to give our LO Neosure but was still not gaining enough weight was sent to GI doctor who then told us to fortify the formula to 27 Cal. Our LO gas gained a decent amount of weight and is back to the standard 22 Cal. We are happy with the weight gain however our LO is still suffering from terrible gas and constipation. Doctors suggested giving apple juice however we see little relief but want us to continue with Neosure because it is the best at this moment. Very happy with this product, just hate seeing my LO in pain with gas and constipation.
Date published: 2018-05-23
Rated 5 out of 5 by from Worked For Us I had extreme skepticism and concerns before using this product with the reviews I read. Fortunately our baby boy who is 6 weeks old has responded well to it with no issues. Our doctor in the hospital said customers only write bad reviews, so here's a good one to give you some hope.
Date published: 2018-05-15
Rated 5 out of 5 by from Worked wonders on my Preemies I had a set of premature Twins (4 lbs 6 oz and 5 lbs 7 oz). Our pediatrician will only recommend NeoSure. There's no other replacement like it on the market. It's put the weight on my babies. And they are both happy and healthy.
Date published: 2018-04-26
Rated 5 out of 5 by from Awesome product for Micro Preemie Weight Gain My son was born at 26 weeks. The NICU supplemented my breast milk with the Neosure 22cal and I continued once home for his first 5 months. At 6 months I transitioned him to complete formula bottles. The Neosure 22cal has been amazing for my son. He has gained weight and length. We have experienced constipation but nothing severe. A little ounce of pear juice helps with it. I highly recommend this product for Micro-Preemies.
Date published: 2018-04-19
Rated 1 out of 5 by from Constipated Twins I pretty much have the same problem as shelbiwelbi. My twins were born March 3rd at 32 weeks. While they were in the NICU, they were taking the Ready to Feed bottles. When they were discharged 13 days later, we were sent home with a couple days worth of the bottles as well. Both boys were having regular bowel movements a couple times a day but about a day or two after switching to the powder I noticed that they both were constipated. Immediately after they eat, they grunt and strain to produce a bowel movement that sometimes never happens. At some point of the day, if a bowel movement finally happens, they resemble rabbit pellets or a hard ball. (SORRY IF THAT'S TOO MUCH INFO) Like the previous poster stated, this too breaks my heart and makes me want to cry when I see the pain in their faces from the issues they are having. I came to this site to gather some info before switching the formula. My suspicion seemed to be confirmed and I also see that my babies aren't the only ones having this problem.
Date published: 2018-03-31
Rated 1 out of 5 by from Constipated my daughter severely My daughter was born at 34 (almost 35) weeks and was in the NICU for 2 weeks. While she was there she was given the ready made bottles of this formula to supplement for breast milk. Thankfully I was producing a good amount of milk and for the most part she didn’t even have to drink the formula, but even before she was drinking 100% breast milk she was never constipated, gassy, or fussy. The NICU sent us home with a can of the Neosure and her pediatrician gave us 3 cans as well when she found out my milk supply started to decrease. At about 5 weeks I had to start supplementing with formula and I noticed an immidiate change. My daughter (who normally pooped after every feeding, every 3 hours) was pooping once a day, and she struggled all day because she was constipated. She was in so much pain, it made me want to cry. I did my research on the internet and found out that several other parents complained about the same problem. I’ve also read that this formula helps premie babies gain weight, which is great, but my daughter had no problem gaining weight before the formula. But I’m not sure the payoff is worth the pain. The only good thing I have to say about the formula is it helped my daughter sleep longer.
Date published: 2018-03-30
Rated 3 out of 5 by from Good but causes gas issues My twins are using neosure after being discharged from the nicu. I noticed they were fine while using the formula in the nicu but experienced constipation and bad gas when at home. I'm assuming this is due to the powder versus ready to feed. What is the difference in the formula blend that would make the ready to feed easier to digest?
Date published: 2018-03-26
Rated 1 out of 5 by from This product causes severe gas My son was born premature at 33 weeks. During his time in NICU he was given the ready made Neosure. We continued with neosure once we were released but switched to powder due to cost. I'm assuming its the same product, however, my son has severe gas pains after each feeding. He turns red, grunts, pushes, high cries to release a small air from his bottom. I know babies can have normal gas, but this is not normal. Peditrician does not want to change formula yet and waiting to see at his next apt. One positive my son has gained weight BUT at what cost- its painful to see him struggle with gas.
Date published: 2018-03-20
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