Similac® NeoSure®

Promotes catch-up growth during your premature baby’s first 12 months


Your premature baby didn’t get her full 9 months in the womb, so her body is working hard to catch up.

Help support her development in the first full year by feeding her Similac NeoSure, a nutrient-enriched* formula for babies who were born prematurely.


Supports excellent growth during baby’s first year.1

  • Increased protein, energy, vitamins, and minerals compared to term infant formula
  • Extra calories for growth
  • Calcium and phosphorus for baby’s growing bones

Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula.1 Has OptiGRO to support your baby's brain and eye development.

Learn more about the nutritional needs of your preemie.

Get tips for keeping your baby’s immune system strong.

Learn why catch-up growth is important.

* Increased protein, vitamins, and minerals compared to term infant formula.
Reference: 1. Carver JD, et al. Pediatrics. 2001;107:638-689.

Similac NeoSure 13.1 oz formula with Iron for preemies

Available In:

13.1-oz Powder

1-qt Ready to Feed

2-fl-oz Ready to Feed

For babies who were born prematurely

Nutrition Information

Powder / 13.1 oz

Serving size: 100 Cal (4.5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac NeoSure
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Similac NeoSure Reviews

Rated 4 out of 5 by from Great for weight gain but not for constipation My baby girl was born at 36wks1day. She had done awesome with Neosure until about 2 weeks ago. She is 7 weeks today. She stays constipated and fussy. She goes for her 2 month check-up in a few weeks and I’m going to see about changing her to another high calorie formula. It is very expensive also! There aren’t any coupons or help anywhere!
Date published: 2019-01-04
Rated 5 out of 5 by from Premie twins thriving because of Neosure! Our twins were born at 29 w 5 days at 3 lb 14 oz and 3 lb 2 oz. They primarily received Neosure in the hospital due to low milk production on my end. They were able to go home at 35 weeks 3 days and have been doing great ever since (now up to 15 and 13 pounds at 5 months - still on Neosure). We use Amazon subscribe and save to offset some of the additional cost, as it is definitely pricey, but it’s specialty so the price tag is understandable. We do plan to stick with other Similac products once the twins switch off Neosure as we’ve tested some of the other varieties (samples we received) and they’ve responded well.
Date published: 2019-01-01
Rated 4 out of 5 by from Great product Mother of a little one born at 28 weeks. He's doing great little gassy but being born at 3 lbs 6oz and now we r 12 lbs 1 oz he's gaining and doing great. great product highly recommended.. only thing wish the product wasn't so expensive and assistance could b provided to the parents.. as parents of premature babies we do have alot of expensive bills.. just help those that could use a helping hand...
Date published: 2018-12-31
Rated 5 out of 5 by from Awesome for my baby! Love this milk! My 4mo baby loves it!
Date published: 2018-12-19
Rated 4 out of 5 by from Expensive, but only option Our twin boys were born at 29 weeks. Mayo Clinic recommended this formula to us (Twins born there) so that is why we use it. The price tag is steep, especially since we have mounting medical bills from their long NICU stay. My one son does fine on it, but the other is so gassy and spits up often. Overall, we recommend it as we don’t have many other options...mainly wish it were cheaper.
Date published: 2018-12-18
Rated 4 out of 5 by from My babies are doing great on the Neosure I have seen a few negative reviews on here so I figured I'd share my experience. This product is not perfect, but it works. My twins were born at 35 weeks have always been on Neosure. Admittedly, they had less digestion issues with breast milk, but breast milk wasn't an option for us for very long. My babies were both tiny so they needed to gain weight fast to stay healthy and graduate from the NICU. Neosure got the job done. At two months my kids are happy and healthy 8 pounders thanks to Neosure, so I am happy with it. Maybe there is room for improvement but I am just grateful it was an option for us.
Date published: 2018-12-15
Rated 4 out of 5 by from Great product, low supply, high price tag I gave birth to two 2-pound premies 11 years apart, and both thrived on Neosure. Lately, I’ve been finding it so hard to get it at the stores as they only have 1 or two at the shelves at a time. Also, the high price tag of Neosure with all the other expenses added to having a premie surely hits hard. Other than that, I’m happy there’s a formula meant for babies like mine.
Date published: 2018-12-09
Rated 4 out of 5 by from I appreciate this product but have a suggestion I am the mother of a preemie born at 34.5 weeks. This product is a great one produces little to no excess gas, stores conveniently and always fresh however i have a suggestion. Im not sure whose idea it was to make the scope inside the container the same size as the opening of the bottle. When preparing the powdered formula there is always waste outside the bottle which allows for inaccurate preparation and measurement. Perhaps if the scoop was deeper and more narrow allowing for better preparation I would have rated this product a perfect 5. I love that Similac has always been a product that a parent could rely on however its the small things that make consumers appreciate a product.
Date published: 2018-12-02
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