Similac® NeoSure®

Promotes catch-up growth during your premature baby’s first 12 months


Your premature baby didn’t get her full 9 months in the womb, so her body is working hard to catch up. During her first full year, feed her Similac NeoSure, a nutrient-enriched formula for babies who were born prematurely, and help support her development.

Similac NeoSure is now available in a NEW value-size can, which provides over 70% more formula.*


Supports excellent growth during baby’s first year.1

  • Increased protein, energy, vitamins, and minerals compared to term infant formula
  • Extra calories for growth
  • Calcium and phosphorus for baby’s growing bones

Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula.1 Has OptiGRO® to support your baby's brain and eye development.

Learn more about the nutrition needs of your preemie.

Get tips for keeping your baby’s immune system strong.

Learn why catch-up growth is important.

* Versus NeoSure 13.1-oz powder.
† Increased protein, vitamins, and minerals compared to term infant formula.
‡ Compared to term infant formula.
Reference: 1. Carver JD, et al. Pediatrics. 2001;107(4):683-689.

Similac NeoSure 13.1 oz formula with Iron for preemies

Available In:

22.8-oz Powder

13.1-oz Powder

1-qt Ready to Feed

2-fl-oz Ready to Feed

NoPalmOil-Video-2 No Palm Oil/Palm Olein Oil

Nutrition Information

Powder / 13.1 oz

Serving size: 100 Cal (4.5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac NeoSure
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Similac NeoSure Reviews

Rated 4 out of 5 by from Preemie formula Our daughter was born 9 weeks early and in the NICU for several months. She was so tiny and a fighter while in the NICU she was started on NEOSURE, and when able to come home she weighed 5lbs. NEO is helping her grow with all the extra nutrients we are almost at 7lbs but she suffers from gas, spitting up, and constipation. As a first time mother of a preemie I was concerned, her pediatrician advised prune juice, exercises, and gripe water. This seems to help, but every few 2-3 days we cycle through with a very fussy baby. It’s hard being so little. Hoping that with added lbs comes less tummy problems. I wish this formula came in a larger container and at a better price tag, it’s tough to pay 20-30 a canister when the little spits up often.
Date published: 2020-02-06
Rated 1 out of 5 by from It does give my preemie more calories but for nothing Since we switched to neosure she is so uncomfortable and at times miserable and burns all the extra calories trying to pass gas and poop. She hardly gets good rest and i dont feel like the makers of this formula take into account that weight gain at the cost of happiness and being comfortable is is not a fair trade. They should try to figure out how to make this easier on their tummies
Date published: 2020-01-30
Rated 4 out of 5 by from Great for my preemie babys weight gain This is the formula my 27 week preemie recieved in NICU. She is gaining weight great but I think it gives her really bad gas and she seems very uncomfortable. Doing some exercises and massage help with that.
Date published: 2020-01-24
Rated 5 out of 5 by from Great for when breast milk needs a boost! My 28 weeker takes breast milk fortified with neosure. Even when she is not taking in as much as the doctor wishes she would, she is still growing and gaining weight. Thanks to neosure, my once 2 pound baby is over 10 pounds! We were worried in the beginning because we experienced the commonly mentioned gas and constipation, but as she got older those problems resolved on their own and she is doing great!
Date published: 2020-01-11
Rated 4 out of 5 by from Twin preemies My 31 weekers been on neo sure since getting out NICU Twin B tolerates the formula fine and is gaining weight Twin A has been gaining weight but is really gassy and fussy so I might have to switch to something else
Date published: 2020-01-10
Rated 2 out of 5 by from Made my baby very uncomfortable My baby girl was born at 36 weeks. She was in NICU for 7 days and they started her off with Simalac NeoSure continued it when we got home for a week and half more and had to stop giving it to her. She was VERY fussy, very constipated and gassy. Could tell her tummy was in so much pain and would cry alot when she was trying to go she would push ALOT and nothing. I decided to change formula to Similac Pro-Total Comfort. And she is way better with that one. The only one good thing i seen with NeoSure is she did gain weight that she needed, but other than that i wouldn’t use it.
Date published: 2020-01-08
Rated 5 out of 5 by from Works wonders! My little man was born 11 weeks early and weighed 2 lbs 7oz. He was on breastmilk alone for 20 days when the NICU Dr.’s recommended we mix my milk with neosure to help with weight gain. We did this for 3 months and continued on neosure alone afterwards. It has helped him so much in gaining weight and getting back on track! He is now 1 year and 1 month and very healthy and happy!
Date published: 2020-01-08
Rated 5 out of 5 by from Making our little guy chunky!! Our son was born 3 months early Nov 2019 weighing 2lb 4oz and was in the NICU for 62 days. At discharge he was over 5lbs. He's been home for almost 2 months now and at his last weight check he was 11lbs 7oz!! He went from the 70% in weight to 90%!! This stuff works wonders!
Date published: 2020-01-05
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