Similac® NeoSure®

Promotes catch-up growth during your premature baby’s first 12 months


Your premature baby didn’t get her full 9 months in the womb, so her body is working hard to catch up.

Help support her development in the first full year by feeding her Similac NeoSure, a nutrient-enriched* formula for babies who were born prematurely.


Supports excellent growth during baby’s first year.1

  • Increased protein, energy, vitamins, and minerals compared to term infant formula
  • Extra calories for growth
  • Calcium and phosphorus for baby’s growing bones

Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula.1 Has OptiGRO to support your baby's brain and eye development.

Learn more about the nutritional needs of your preemie.

Get tips for keeping your baby’s immune system strong.

Learn why catch-up growth is important.

* Increased protein, vitamins, and minerals compared to term infant formula.
Reference: 1. Carver JD, et al. Pediatrics. 2001;107:638-689.

Similac NeoSure 13.1 oz formula with Iron for preemies

Available In:

Similac NeoSure 13.1 oz formula with Iron for preemies 13.1-oz Powder

Similac NeoSure 13.1 oz formula with Iron for preemies 1-qt Ready to Feed

Similac NeoSure 13.1 oz formula with Iron for preemies 2-fl-oz Ready to Feed

Nutrition Information

Powder / 13.1 oz

Serving size: 100 Cal (4.5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac NeoSure
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Rated 1 out of 5 by from This product causes severe gas My son was born premature at 33 weeks. During his time in NICU he was given the ready made Neosure. We continued with neosure once we were released but switched to powder due to cost. I'm assuming its the same product, however, my son has severe gas pains after each feeding. He turns red, grunts, pushes, high cries to release a small air from his bottom. I know babies can have normal gas, but this is not normal. Peditrician does not want to change formula yet and waiting to see at his next apt. One positive my son has gained weight BUT at what cost- its painful to see him struggle with gas.
Date published: 2018-03-20
Rated 2 out of 5 by from Gassy , projectile vomiting and constipation Oh My! Preemie twins born at 34 weeks and Nicu gave Neosure. They have had Neosure till now at 4 months old. Both have gained weight and seem healthy. BUT....they have gone thru many periods of painful gas, straining from constipation, projectile vomiting and overall crankiness and crying after a Neosure feeding. Not happy with the side effects and their doctor won't suggest an alternative.
Date published: 2018-03-15
Rated 4 out of 5 by from Love it - wish you would have the 8oz ready to feed This has worked great for our son and his weight gain. Just wish you had the 8oz ready to feed bottles, or even the pre-measured on the go packets. Those would come in handy for travel and being out an about.
Date published: 2018-03-04
Rated 5 out of 5 by from Great for gaining weight I had my twins @ 25 weeks they been drinking neosure since day one and their weight has picked up tremendously plus their motor and fine motor skills are all up to date and then some i have nothing good but good things to say about neosure the price is even affordable, the only thing i cannot find in the similac website is a recipe to change 22cal/oz into 28cal/oz ????????
Date published: 2018-02-25
Rated 3 out of 5 by from does the job but pricey and with lots of gas I was told my preemie (born 33 weeks, now 2 months old) needed this formula for the nutritional benefits so I felt I had no real choice but to do it for her health. She is gaining weight beautifully so that's a win, however her gas is REALLY bad with this formula and every feed is crying, cramping gas pains. She's burping ok and I've switched bottles 2 weeks ago to non-colic bottles but there's no help, which only leads me to believe this formula is upsetting her belly. The price is also so so high its a burden on our budget big time.
Date published: 2018-02-23
Rated 3 out of 5 by from Too costly As good as this stuff may be, for those of us just over the income limits for WIC this product is not very affordable. I have an infant who was born at 24 weeks but even with a few coupons that I find, etc. this formula really socks it to you on the price. I wcan she it was more affordable especially for the size cans it’s available in. Good for preemies, bad on ththe pocketbook.
Date published: 2018-02-19
Rated 3 out of 5 by from Bad gas and hard to find! My son was born at 34 weeks and I have been fortifying my breastmilk with neosure since he was about 1 week old. He has been gaining weight fine but, he is constantly grunting/pushing/arching his back to pass gas and it smells rancid! He has finally gotten to the point where he will eat about 1oz and has trouble eating anymore because he is grunting and pushing so hard to pass gas. He has also been getting increasingly fussy and will vomit his entire feeding shortly after eating. I had a sample can of pro-sensitive and switched him to that this morning. I swear I am feeding a different kid! Way better! Neosure is also really hard to find for that I wish the cans were bigger. Most Walmart’s have it but it is usually sold out. Occasionally I will find it at Target but some don’t even carry it.
Date published: 2018-02-12
Rated 3 out of 5 by from Gassy, No Bowel Movement for Days This formula is doing me and my little one no good. My baby stains so hard that she turns red. She hasn't had a bowel movement in days. I didn't have a problem with the ready feed bottles we received when we got discharged from the hospital. Luckily I am enrolled in the WIC program.Something needs to be done about this formula from all the other reviews basically saying the same thing.
Date published: 2018-02-12
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