Similac® NeoSure®

Promotes catch-up growth during your premature baby’s first 12 months


Your premature baby didn’t get her full 9 months in the womb, so her body is working hard to catch up.

Help support her development in the first full year by feeding her Similac NeoSure, a nutrient-enriched* formula for babies who were born prematurely.


Supports excellent growth during baby’s first year.1

  • Increased protein, energy, vitamins, and minerals compared to term infant formula
  • Extra calories for growth
  • Calcium and phosphorus for baby’s growing bones

Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula.1 Has OptiGRO to support your baby's brain and eye development.

Learn more about the nutritional needs of your preemie.

Get tips for keeping your baby’s immune system strong.

Learn why catch-up growth is important.

* Increased protein, vitamins, and minerals compared to term infant formula.
Reference: 1. Carver JD, et al. Pediatrics. 2001;107:638-689.

Similac NeoSure 13.1 oz formula with Iron for preemies

Available In:

13.1-oz Powder

1-qt Ready to Feed

2-fl-oz Ready to Feed

For babies who were born prematurely

Nutrition Information

Powder / 13.1 oz

Serving size: 100 Cal (4.5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac NeoSure
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Similac NeoSure Reviews

Rated 4 out of 5 by from Love it! Just wish it was a little more affordable. Our little guy was born at 29wks 5days. He spent 3 months in the NICU and was started on Neosure there. He did get a bit gassy when he came home, but nothing some over the counter (pediatrician approved) gas drops, & tummy massages couldn't handle. He only had a couple of doses before his stomach adjusted to the volume, and of course bottle feeding itself, as he had been fed through a feeding tube for the majority of his NICU stay. Weight gain was never a concern with him, and I believe a large part of that was due to this formula, & an abundance of prayer of course! The only downside, and reason I gave it 4 stars, has nothing to do with the quality of this product, but with the cost. Each can is almost $20.00, and now that he's going on 9mo (6mo adjusted) he goes through 2 and a half cans a week. We don't qualify for any sort of financial assistance so on top of our new homes mortgage (purchased just before finding out I was prego), hospital bills, daycare, and life in general, it's getting pretty difficult to keep up with little man's appetite. All in all, I would still whole heartedly recommend this product for preemie babies!
Date published: 2018-07-16
Rated 3 out of 5 by from Constipated and Gassy This formula both ready to feed and powder made my 36week premie extremely gassy and constipated of course the NICU was feeding him this and he did fine in the hospital with an IV but once we got home his bowel movements have been maybe once a day if that. I can tell he’s hydrated because he’s peeing a lot and it’s a light in color. But he has been extremely unconfortable since being home with how gassy and consitpated he has been. With being a new single mother it has been very tough for me to comfort him when he has his rough days. We will be consulting with his pediatrician about another formula that will be better for him. Originally he was started on Similac because that’s what WIC here prefers, but I’d rather pay more out of pocket and have my baby comfortable without the headache.
Date published: 2018-07-07
Rated 4 out of 5 by from Great for preemies but with some caveats. Our twins were born at 34 weeks so they have been on NeoSure since the get go. It has helped them tremendously. However, now that we are a few months old and still on it, we have noticed the following: - NeoSure makes our preemies constipated with less bowel movements than with breastmilk - NeoSure makes them EXTREMELY gassy which creates fuzzy nights - NeoSure cans are so tiny and our twins go through so many of them that it’s a hassle. These bottles are $20 each and we go through a can every day and a half so imagine the huge expenditure. I wish NeoSure would listen to the consumers and make some fixes to their product. Apart from that, this is great for our preemies.
Date published: 2018-06-28
Rated 4 out of 5 by from Great Product Our little one has been on this since day one after being 4 weeks early. Just wish it came in bigger containers since even after almost 6 months our dr says our little one won't be stopping it anytime soon. Just wish we would get more coupons since its so expensive for a tiny can.
Date published: 2018-06-25
Rated 4 out of 5 by from Definitely pros and cons This formula is great for my 28 weeker, whom is now 6 months. We had slight consiptation (all babies get constipated) but this formula still works great. Super grateful except I really really wish they made a bigger can!!!!! I’ve heard excuses about “because kids don’t drink it for long” but that’s a lie. Since birth it was added calories to my BM but now it’s straight neosure and her pediatrician doesnt see us changing so it’s kind of a pain. And I wish the stores sold it in the box, it’s nice to get some from the NICU follow up and it have the 2$ coupon!
Date published: 2018-06-15
Rated 5 out of 5 by from Neosure is excellent boon for premature babies i had a premature baby boy who was born a month before the expected date. me and wife were so worried about the health of the baby during the time of the delivery. for our good, the baby was born healthy and was weighing 5.5 pounds which is less to the standard charts that are recommend. we met our pediatrician and raised our concern and she advised to give neosure starting the second monthly checkup. As my wife was also feeding and her milk was not completely enough we decided to do Neosure during morning and afternoon. Initially the baby has gas issues with neosure and we diluted the milk with more water to help him not to run into any digestion problems. We slowly increased from 2.5 FL to 3.5 FL. Sooner from third checkup, we saw excellent result in terms of baby hieght, weight and head circumference. He is also very active. i would highly recommend Neosure to premature babies and it will work wonders if we are cautious of how much dilution your baby should take. it would be nicer here if they allow to share the pics of the baby before and after the neosure consumption so we really see a pictorial difference:) Thanks Samilac for being another mom for my baby .
Date published: 2018-06-12
Rated 2 out of 5 by from Gas and discomfort My baby has been on Neosure since he was born at 4 pds. His doctor suggested the ready to feed neosure, which I didn't have any problems with. After a while I switched over to the powder and it seems like he's been extremely gassy and has started spitting up way more frequently. During night time hours he seems to grunt and whine as if he has an upset stomach. I'm currently looking for an alternative because it breaks my heart to see him moan in pain. This is a great product to help your baby gain weight, but I don't recommend keeping your baby on this formula very long.
Date published: 2018-06-07
Rated 5 out of 5 by from Great for my preemie twins! My twins were born at 31 weeks with an emergency c-section. My daughter was 3 lbs 15 oz and my son was 4 lbs 7 oz. Both of them were feed breastmilk with the NeoSure 22 cal powder to help them gain weight. My daughter came home after 5 weeks and my son after 7 weeks. My little girl still needs the NeoSure added to her Breastmilk to help her gain weight since she is in the bottom 5% on the growth chart. The formula can be found at all my local stores (Publix, Target, Walmart, BabiesRus), however, it is quite expensive.
Date published: 2018-06-04
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