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Similac® NeoSure®

Promotes catch-up growth during your premature baby’s first 12 months


Your premature baby didn’t get her full 9 months in the womb, so her body is working hard to catch up. During her first full year, feed her Similac NeoSure, a nutrient-enriched formula for babies who were born prematurely, and help support her development.

Similac NeoSure is now available in a NEW value-size can, which provides over 70% more formula.*


Supports excellent growth during baby’s first year.1

  • Increased protein, energy, vitamins, and minerals compared to term infant formula
  • Extra calories for growth
  • Calcium and phosphorus for baby’s growing bones

Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula.1 Has OptiGRO® to support your baby's brain and eye development.

Learn more about the nutrition needs of your preemie.

Get tips for keeping your baby’s immune system strong.

Learn why catch-up growth is important.

* Versus NeoSure 13.1-oz powder.
† Increased protein, vitamins, and minerals compared to term infant formula.
‡ Compared to term infant formula.
Reference: 1. Carver JD, et al. Pediatrics. 2001;107(4):683-689.

Similac NeoSure 13.1 oz formula with Iron for preemies

Available In:

22.8-oz Powder

13.1-oz Powder

1-qt Ready to Feed

2-fl-oz Ready to Feed

neosure-video NeoSure video

NoPalmOil-Video-2 No Palm Oil/Palm Olein Oil

Nutrition Information

Powder / 13.1 oz

Serving size: 100 Cal (4.5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac NeoSure
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Similac NeoSure Reviews

Rated 3 out of 5 by from If my sons doctor did not recommend it I wouldn’t buy this I do not like this milk. It gives my baby terrible gas every feeding. He can’t sleep and I have to use gas drops. I wish I could switch to something else. It’s frustrating.
Date published: 2020-08-07
Rated 4 out of 5 by from Great Formula with some side effects I agree with most of the mom's on here. My baby girl was born at 34weeks and was immediately placed on Neosure. My baby is very gassy bit it has helped her grow tremendously. I also think this formula is very expensive but it's the only formula she has been on since birth. With Covid cases consistently rising, it's hard to find and the stores run out so fast but it's so expensive you can't buy 4 or 5 quarts/cans at a time. I need coupons, vouchers, or something to help with the cost.
Date published: 2020-08-07
Rated 5 out of 5 by from Great for my 6 week early son Helped him gain the weight he needed to leave the NICU after 6 days and come home
Date published: 2020-07-01
Rated 5 out of 5 by from Both my babies have used/ currently using this formula Both my children have needed this formula. I love it. It has helped my son put back his birth weight and then some already. He was born 35 weeks 4 days. And my daughter has exceeded expectations and is currently a healthy and brilliant 4 year old.
Date published: 2020-06-21
Rated 2 out of 5 by from Good for weight , poor for bowls Had my baby at 37/38 weeks and even tho that is considered full term my baby was tiny for his game age weighting 5 pounds and 1 oz. So they put him on Neosure to make sure he gains weight which he is. But the thing is he is fussy and has had problems with constipation and he has just turned 2 months and that's bout how long he's had the issue. Plus with the gas as well.Not really sure what to do they want him to stay on it but my baby is miserable trying to pass stool and almost nothing is helping at this point.
Date published: 2020-06-12
Rated 4 out of 5 by from Great "Stuff" My baby boy was born at 27 weeks. He weighed 1lb, 14ozs at birth. He spent 2 months in the NICU. He was 4lbs when he came home. When he was discharged, they told me to give him Neosure twice a day and breastmilk. He wouldnt tolerate the breastmilk. (I know, weird) He is now on Neosure exclusively. He gained 2-3lbs in less than a month. The only thing that I had a minor concern about is, he is gassy and has trouble moving his bowels. It takes a few days for him to go. If you can figure out a way to control the gas and constipation Neosure causes, this would be the PERFECT formula.
Date published: 2020-05-14
Rated 5 out of 5 by from Awesome sauce My twins were born at 36 weeks , no NICU time . . this has been the one and only formula that they have been on . . they are now 6 months weighing 20lbs a piece ! I didn’t have to switch formula or go through the motions of trying and testing what worked for Them ! This was the first and only formula my boys have had to try out
Date published: 2020-05-05
Rated 1 out of 5 by from 36 weeks My daughter was born at 36 weeks and a blessing. We are now week 2 of her life and she has been constipated, fussy and extremely gassy on the neosure ilk We have four other children who were all pre mature due to my health condition but they never had any of these issues and was never on neosure. Gas drops help for a short period of tie but I should not have to give her gas drops after every feeding. I have made a doctors appointment for tomorrow to get her off this milk and so she can have a peaceful sleep.
Date published: 2020-04-27
Rated 5 out of 5 by from Good quality It has good name and they stand by it
Date published: 2020-04-24
Rated 1 out of 5 by from weight gain but lots of gas My son is a 29 weeks premie. The hospital put him on neosure. He had painful gas and was crying a lot. PCP Changed formula to enfacare from enfamil and my son is better.
Date published: 2020-04-24
Rated 5 out of 5 by from My twins love this My babies were born 35 months and had to stay at NICU for roundly 2 weeks. A variety of premature infant formula was tried, and Neosure turned out the best fit. After NICU we fed them breast milk and formula simultaneously (6 times with Neosure and 2 times with breast milk per day). We were very happy to see how Neosure supported my babies' growth in both physical and body strength. Now at 3 month their weight and length are above US newborn average.
Date published: 2020-04-23
Rated 2 out of 5 by from Great for growth but poor for the digestive tract. I had my son at 30 weeks and 5 days, was 9 weeks abd 2 days premature and spent 29 days in the NICU. Once they sent us home, he was given neosure and had so many issues with pooping. It would be 3-4 days before he would give a solid poop and when he did they would be nearly hard and it was uncomfortable for him to pass. Not to mention the gas and bloated tummy. As far as his growth, it’s off the charts! He’s doing amazing in that area and I have to give credit to my breast milk plus the neosure.
Date published: 2020-04-10
Rated 5 out of 5 by from Been amazing with my twins My twin boys were born at 32 weeka weighing 3 lbs and after my breast milk supoly wasnt enough they were givin neosure to supplement for calleries. Bedire leaving the hospital at 6 weeks old both werw 100% on neosure. It has been amazing. They are 5 montys old next week and weigj 14 lbs each.
Date published: 2020-04-08
Rated 5 out of 5 by from Great for Preemie Weight Gain I am a mom of twin boys who were born at 23 weeks. My first son was 1 pound 6 ounces and my second was 1 pound 4.5 ounces. We were in the hospital for 5 months and Neosure was used along with the breast milk I was producing to increase their calories, which it did. Both my sons were over 10 lbs when we left the hospital and after my milk supply dried up I moved to using the Neosure product 100%. It has been instrumental in helping my miracle babies grow and develop and I am so thankful for this product and the additional calories it offered my twins who desperately needed it.
Date published: 2020-03-18
Rated 5 out of 5 by from Awesome I had my lil guy at 36 weeks on my livingroom floor just me and him. An hour after contractions started.....4 minutes after my water broke...20 seconds after I called 911 . Paramedics were here in 3 minutes...regardless we had a 2.5 week NICU stay with feeding tubes. This formula has been a life saver I now have a chunky 14 lbs 3.5 month old. It is very very hard to find in Saint Louis. I am very worried with the Coronavirus I wont be able to find it. I recieve WIC and have vouchers for 10 cans however I end up buying it out of pocket (which I cant afford) because I can never find 5 cans at 1 place.
Date published: 2020-03-18
Rated 5 out of 5 by from My daughter was born at 35 weeks and was given this formula I was given this formula at the hospital and was drinking this while in the NICU and was drinking 40ml to 2 ounces every 3 hours. she hasn't any issues and it is helping her grow from 5lbs to 7lbs and counting I recommend to any mother that has a baby is born at 35 weeks or less
Date published: 2020-03-16
Rated 3 out of 5 by from Expensive I have twins and we are supposed to stay on this but I agree with the other posts it’s just so expensive especially for feeding two babies ! I am going to have to talk to the pediatrician on different options because of price! I’d love more coupons because I do love Neosure !
Date published: 2020-02-23
Rated 2 out of 5 by from Causes pain and discomfort I have twins born at 34 weeks and was sent home from NICU with this formula. The first 2 weeks there was no problems but things took a turn. My smaller baby is spitting up consistently. She is constipated and in a lot of pain. She is having a hard time sleeping and very fussy for hours. On top of all of this the formula is extremely expensive for 2 babies eating 2oz every 2-3 hours. The weight gain is great but I’m not sure it’s worth it. You all should consider coupons or a cheaper options for premature babies. I’m calling the pediatrician tomorrow for other options...
Date published: 2020-02-18
Rated 4 out of 5 by from Preemie formula Our daughter was born 9 weeks early and in the NICU for several months. She was so tiny and a fighter while in the NICU she was started on NEOSURE, and when able to come home she weighed 5lbs. NEO is helping her grow with all the extra nutrients we are almost at 7lbs but she suffers from gas, spitting up, and constipation. As a first time mother of a preemie I was concerned, her pediatrician advised prune juice, exercises, and gripe water. This seems to help, but every few 2-3 days we cycle through with a very fussy baby. It’s hard being so little. Hoping that with added lbs comes less tummy problems. I wish this formula came in a larger container and at a better price tag, it’s tough to pay 20-30 a canister when the little spits up often.
Date published: 2020-02-06
Rated 1 out of 5 by from It does give my preemie more calories but for nothing Since we switched to neosure she is so uncomfortable and at times miserable and burns all the extra calories trying to pass gas and poop. She hardly gets good rest and i dont feel like the makers of this formula take into account that weight gain at the cost of happiness and being comfortable is is not a fair trade. They should try to figure out how to make this easier on their tummies
Date published: 2020-01-30
Rated 4 out of 5 by from Great for my preemie babys weight gain This is the formula my 27 week preemie recieved in NICU. She is gaining weight great but I think it gives her really bad gas and she seems very uncomfortable. Doing some exercises and massage help with that.
Date published: 2020-01-24
Rated 5 out of 5 by from Great for when breast milk needs a boost! My 28 weeker takes breast milk fortified with neosure. Even when she is not taking in as much as the doctor wishes she would, she is still growing and gaining weight. Thanks to neosure, my once 2 pound baby is over 10 pounds! We were worried in the beginning because we experienced the commonly mentioned gas and constipation, but as she got older those problems resolved on their own and she is doing great!
Date published: 2020-01-11
Rated 4 out of 5 by from Twin preemies My 31 weekers been on neo sure since getting out NICU Twin B tolerates the formula fine and is gaining weight Twin A has been gaining weight but is really gassy and fussy so I might have to switch to something else
Date published: 2020-01-10
Rated 2 out of 5 by from Made my baby very uncomfortable My baby girl was born at 36 weeks. She was in NICU for 7 days and they started her off with Simalac NeoSure continued it when we got home for a week and half more and had to stop giving it to her. She was VERY fussy, very constipated and gassy. Could tell her tummy was in so much pain and would cry alot when she was trying to go she would push ALOT and nothing. I decided to change formula to Similac Pro-Total Comfort. And she is way better with that one. The only one good thing i seen with NeoSure is she did gain weight that she needed, but other than that i wouldn’t use it.
Date published: 2020-01-08
Rated 5 out of 5 by from Works wonders! My little man was born 11 weeks early and weighed 2 lbs 7oz. He was on breastmilk alone for 20 days when the NICU Dr.’s recommended we mix my milk with neosure to help with weight gain. We did this for 3 months and continued on neosure alone afterwards. It has helped him so much in gaining weight and getting back on track! He is now 1 year and 1 month and very healthy and happy!
Date published: 2020-01-08
Rated 5 out of 5 by from Making our little guy chunky!! Our son was born 3 months early Nov 2019 weighing 2lb 4oz and was in the NICU for 62 days. At discharge he was over 5lbs. He's been home for almost 2 months now and at his last weight check he was 11lbs 7oz!! He went from the 70% in weight to 90%!! This stuff works wonders!
Date published: 2020-01-05
Rated 5 out of 5 by from This product helps give my baby the nutrients and calories she needs My baby wasn't a preemie and was actually born at 41 weeks and 4 days. She was 6 lbs 7 oz at birth. At her 2 month appointment it was discovered that she wasn't gaining weight nearly well enough on breast milk alone. Her pediatrician recommended combo feeding and using this formula to help her catch up and gain the weight necessary to support healthy growth. Due to the added calories and nutrients, my daughter is back on track and doing much better now that she is getting enough to eat.
Date published: 2020-01-04
Rated 4 out of 5 by from Helps with weight gain This was recommended for my 32 week old preemie. However, I think it makes him gassy and constipated.
Date published: 2020-01-04
Rated 5 out of 5 by from This product are great for preemies Helped my twins gained weight. They were born Dec 27, 2019. One twin is still in NICU. Hopefully he will be home soon.
Date published: 2020-01-03
Rated 4 out of 5 by from Great Results Our baby was born at 34 weeks and 4 lbs 13 oz, at discharge we were at 4 lbs 6. We checked with pediatrician and she recommend Neosure. After that appointment we gained an avg of 1 oz a day until our next. Only issue was a fussy gassy baby with slight constipation.
Date published: 2020-01-03
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