Similac® NeoSure®

Promotes catch-up growth during your premature baby’s first 12 months


Your premature baby didn’t get her full 9 months in the womb, so her body is working hard to catch up.

Help support her development in the first full year by feeding her Similac NeoSure, a nutrient-enriched* formula for babies who were born prematurely.


Supports excellent growth during baby’s first year.1

  • Increased protein, energy, vitamins, and minerals compared to term infant formula
  • Extra calories for growth
  • Calcium and phosphorus for baby’s growing bones

Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula.1 Has OptiGRO to support your baby's brain and eye development.

Learn more about the nutritional needs of your preemie.

Get tips for keeping your baby’s immune system strong.

Learn why catch-up growth is important.

* Increased protein, vitamins, and minerals compared to term infant formula.
Reference: 1. Carver JD, et al. Pediatrics. 2001;107:638-689.

Similac NeoSure 13.1 oz formula with Iron for preemies

Available In:

Similac NeoSure 13.1 oz formula with Iron for preemies 13.1-oz Powder

Similac NeoSure 13.1 oz formula with Iron for preemies 1-qt Ready to Feed

Similac NeoSure 13.1 oz formula with Iron for preemies 2-fl-oz Ready to Feed

Nutrition Information

Powder / 13.1 oz

Serving size: 100 Cal (4.5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac NeoSure
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Rated 5 out of 5 by from The best This is the best formula ever!my baby girl was born 26 weeks, being a micro preemie this formula did the best,she never had any problems with it,no gassy, no colic,none!they used this formula while in NICU ,now at home I'm still using it,until she's 1 year adjusted, it's full of minerals, vitamins, nutrients It's our life saver!!!! Thank you so much SIMILAC!!!!
Date published: 2017-05-06
Rated 5 out of 5 by from Just AMAZING! We have twin boys that were born @ 34 weeks. They were not making weight gains by just eating breast milk. The NICU staff and doctors decided to give them this formula every 3 hours. They started to make a great change and only had to stay at the hospital for 13 days. We are so over the moon with their gains. Their doctor has said that since they are doing so well with this formula that they will stay on this for at least the first 6 month or maybe longer. The only down side to this product is that we cannot find any coupons for this formula. We have found coupons for other Similac products, just not this one. We would love to be able to find it in bulk so that the price might be cheaper. If there are any other parents that have found this product at a discounted price or has found a place to get coupons for this product pleas post on this site. Sincerely, One Blessed Family
Date published: 2017-05-05
Rated 5 out of 5 by from Thank you My son was born at 31 weeks at only 3 lbs he is only 2moths now and is almost 7 lbs he seems to be gaianing a good chunk of weight since I stopped with donor milk in the hospital and he started on this formula thank you similac for helping feed my baby #fedisbest
Date published: 2017-05-02
Rated 4 out of 5 by from Good gains, but major gas and pain! My daughter was born at 35 weeks and spent three weeks in the NICU. She was perfectly healthy, but needed to gain weight and learn to eat. She was on breast milk supplemented with Neosure for a while, and now she's on mostly breast milk with a few pure Neosure feeds a day. It has really helped her gain weight, but the gas (and accompanying pain) it causes is a real drawback. Both the NICU nurses and our pediatrician recommended gas drops, which we use, but they only seem to help a little bit. It also backs her up; we went from having several small stools a day to one large stool every 2-3 days that is hard for her to pass. So, it's great that she's gaining weight, but there are some drawbacks for her comfort. Also, I can only find small cans at the store, and they are EXPENSIVE - we use about a can a week, and at roughly $20/can, it really adds up. I can't find any coupons for this product, either, which is incredibly frustrating. I will do whatever I need to do for my daughter, but this is an added expense we don't need after spending a month in the NICU.
Date published: 2017-04-30
Rated 4 out of 5 by from Gaining fast with minor issues Our son was born 26 weeks and was in the NICU for 12 weeks after and has been on the neosure for the last few weeks after the mother's milk came to a stop. He obviously needs the food and nourishment and this has worked great! He's gaining quickly despite his premature lung disease which makes it hard to eat large quantities at one time. The downfall is the gassiness; and with a herniated belly button it makes it unbearable to watch him in agony most of the time. We've gotten stomach suppressants to help which made a difference but now he has a bowel movement almost every meal time. Also bigger and cheaper cans would make this entire process that much easier! Overall this has been a great help to our little boys development!
Date published: 2017-04-30
Rated 5 out of 5 by from Good product for preemies I had twin girls on 3/22/17 and they spent time in NICU. While there they were given Neosure ready made bottles. We continued to use the bottles and then transitioned to the powder. With having twins we go through a can every other day and it is expensive and hard to find in stock. It would be helpful if there was a store locator which told you which stores carried this formula. It would also help if it was available in a larger size for people feeding multiples. My daughters have gained weight since leaving the hospital and our Pediatrician said to continue to use but the pain one of them gets from the gas is unbearable to watch her strain from gas and constipation.
Date published: 2017-04-30
Rated 4 out of 5 by from Hard to find, efficient but causes tummy issues, expensive My son was born at 34weeks on 3/30/17. The nicu started him on neosure. He was getting breast milk and the neosure 50/50. My milk has been drying up so now he is getting mostly neosure. Since this change he went from 2-3 bowel movements a day to one large bowel movement every 2-3 days. He arches his back in pain and turns bright red and cries from gas. The pediatrician said this was okay. It pains me to see him so gassy and uncomfortable. But I do believe the benefits outweigh the cons in my situation. I live in NYC, there are 8 stores near me (cvs, rite aid, duane reade, walgreens) out of the 8, ONLY 2 had it in stock and each store ONLY had one can! How do we get these stores to stock up?! I can only use the coupons mailed to me in store so this causes a problem from me. Also, this formula is expensive but knowing that it works well in helping him gain weight it makes sense. With the similac strong rewards I don't believe this formula qualifies because it doesn't come in a 12oz powder can.
Date published: 2017-04-28
Rated 5 out of 5 by from Great for our Micro Preemie Our granddaughter was born at 25 weeks weighing only 1 lb 2 oz. She was in the NICU almost 5 months. She is home and thriving well on Neosure. She is almost 10 lbs now and is almost 8 months old actual. She has a G Button that she is fed through but we pray she will one day be able to take full bottles. We are pleased with how well she is growing on the Neosure. The cans are very expensive so I'm hoping you could send some coupons to help our little miracle baby keep thriving and growing.
Date published: 2017-04-27
Rated 5 out of 5 by from Helped her gain weight, but caused incredible Gas We have used Neosure on our daughter who was 6 weeks premature. It helped her put on a significant amount of weight. But she experiences a lot of gas, and her belly bloats to a point that we were very concerned. She's doing very well though.
Date published: 2017-04-26
Rated 5 out of 5 by from Awesome for preemies Babygirl was born at 28 wks back in January, she's been taking breast milk fortified with formula since birth. Didn't have a problem the whole 9 wks in NICU. Now that baby is 3 months old, she's having a lot of gas and colic. Feel bad seeing my little one in so much pain but I have seen how much neosure has helped with her developement and I know the benefits out weigh the cons. I have seen my less than 3lb preemie grow into an 11lb 3 month old and I would recommend this formula to any NICU parent. It's not so bad now with baby taking fortified breast milk, but with my milk drying up and her only on formula I'm scared it's going to get too expensive really fast. Is there any kind of discount program or coupons you offer? Only issue is the price, but other than that this is an awesome product for preemie parents.
Date published: 2017-04-26
Rated 5 out of 5 by from Great! My son was born just shy of 33 weeks and the nicu supplemented breastfeeding with neosure. It has helped so much with his weight gain and getting him the extra nutrients he needs. However, he definitely does get gassy! At times, he seems a bit constipated but overall it has been great for my son and he has thrived.
Date published: 2017-04-26
Rated 3 out of 5 by from Want to feed my preemie, but makes her so gassy The NICU fed the 2 oz ready made bottles to my daughter for two weeks while in their care and the pediatrician insisted we continue feeding it 2 times a day (every other feeding is pumped breast milk b/c preemie daughter never latched correctly) . I love the idea behind this product and my daughter seems to like it going down . It fills her up nicely. But a half hour to an hour later, my poor baby cries and shrieks in pain. Non stop gas, causing her to climb my chest and arch her back in agony .many times it comes out of her nose. It's horrible. I've tried adding gas drops, gripe water, colic drops, and it never fails. She struggles for about an hour to get the gas out. I informed my pediatrician of this, but she believes the benefits of neosure outweigh the negatives. So my advice is to proceed with caution; if your baby can handle it, great- but beware of its gas inducing prioperties.
Date published: 2017-04-26
Rated 4 out of 5 by from Neosure is such a wonderful product for our preemie except the cost for parents Our 26 weeker had mothers milk and then we got to switch to Neosure as the supplies went down. Our baby had to take neosure with oatmeal which really helped her to feed without any apnea or brady. But Neosure is too expensive for us.
Date published: 2017-04-25
Rated 4 out of 5 by from Works great for packing on the weight! My son was born at 35 weeks, somewhat small for gestational age. He had a little hiccup that kept him in the nicu for 3 weeks and he was started on NeoSure. Has worked great for him gaining weight, and he tolerates the formula fairly well. However I agree with others that it makes him very gassy and a bit constipated as well. I give some breastmilk, which helps move things along...but he is still a gassy baby. Also, the powder formula, no matter how hard I try does nto dissolve very well. He much rather have the ready-to-feed, which unfortunately is quite costly. In general this formula is quite costly. I cannot imagine how much parents of multiples spend on formula!
Date published: 2017-04-24
Rated 4 out of 5 by from This is a good product Our little one was born 2/27/17 at 34wks. While in nicu she used this along with expressed breast milk. My milk never came in fully so after she came home I've only used the formula. she has gained weight with this formula and is on track to be at weight at her upcoming appointment. I like the formula because of that reason, however my little one has experienced a lot of gas and stomach discomfort. I've been told that the gas will pass in a couple weeks so we are trying to hold out to see if it does. I would recommend it with a caution about the gas.
Date published: 2017-04-21
Rated 5 out of 5 by from Great product for my preemie just super expensive My baby was born 3.30.17 at 35 weeks. This formula has helped her pack on the weight. She doesn't have any gas or spit up issues. Since she was in the nicu we have to make it 24 calories instead of 22. She tolerates it well. I would recommend this product to any preemie mom!!
Date published: 2017-04-20
Rated 4 out of 5 by from Helped my triplets grow My triplets were born on 3.30.17 and one of my girls had to spend time in the NiCU since she was only 4 pounds 11 ounces at 32 weeks. Their pediatrician wants them to continue with neosure. Within in two weeks time, my triplets each gained a pound from this formula. However, the formula makes them extremely gassy causing intense discomfort. The formula makes it hard for them to have a bowel movement without crying as well. Since my babies need to grow, I have to stick with this formula. The formula is super expensive and since I have triplets, they go through one can a day. It would Be great if there were specials, coupons and/or discounts on the formula.
Date published: 2017-04-20
Rated 4 out of 5 by from Great, but wish it came in bigger sizes for Multiples! We have twin boys who have been on NEOsure since we came home. It helped our boys gain weight right off the bat and has worked great for enhancing my breastmilk and then transitioning to only formula. The only suggestion i have is maybe create a bigger size, now that the kids are older we have to buy up to 7-8 cans to last us through a week or two. I just with it had the bigger containers available like the other similac products! It's worked great for our family though!
Date published: 2017-04-18
Rated 3 out of 5 by from This product work great for our preemie and helping him gain weight. The downside to the product is th wish there were more buying options This product worked great for our preemie who is born at 32 weeks. The major downfall is the gas and constipation he has due to the formula. This formula is also hard to find and only comes in the smaller size for a big price.
Date published: 2017-04-17
Rated 4 out of 5 by from Gassy for my Son .. But I like the product My son was born at 30weeks and stayed in the nicu for 3 weeks, immediately similac neosure wad prescribed , while still in Nicu he started adding weight , part of the reason why we were discharged earlier. But I have observed that it makes him to pass gas alot , then most times twist his back and let out a tiny cry/sound. His bowel movement reduced as well. Apart from these issues , this product is fantastic for Preemies.
Date published: 2017-04-17
Rated 4 out of 5 by from This formula worked great for my son!! .This formula worked great for my son!!
Date published: 2017-04-15
Rated 5 out of 5 by from My baby girl loved it My baby girl was born 6 weeks early and she loved this formula. Never had a issue with this formula and she was on the ready to feed. Also thank u for the coupons similac it helps me out so much and I Wouldn't pick another brand !
Date published: 2017-04-14
Rated 5 out of 5 by from Great help in boosting weight for my Twins! My twins were 3.10lbs and 4.11lbs and lost 1/2 a lb in their first week. They were 5 weeks premature bc they were no longer sharing with eachother and stopped growing in the womb so they had to be delivered early to get them back on track. Their weight was hard to maintain while in the NICU for 2.5 weeks. The nurses/doctors eventually put them on NeoSure to help boost their weight and it worked! My pediatrician has recommended that I keep them on NeoSure until they hit 12 months. It would be really helpful if there were coupons for Twins as we go through at least 2 cans in about 4 days! It is really expensive to maintain along with diapers for 2! Also can you make a bigger canister like the rest of your formulas!?
Date published: 2017-04-14
Rated 5 out of 5 by from I DON'T KNOW WHERE WE WOULD BE WITHOUT NEOSURE My grandbaby was born at 26 weeks and 6 days weighing in at a whopping 1lb 7oz.. He has been on Neosure since he was old enough to start eating. He will be 1 year old on April 17th. He weighs 14.5lbs now. He is still having a hard time with solid food so he will not come off of the neosure yet. He still needs the extra help. Thanks so much!
Date published: 2017-04-13
Rated 5 out of 5 by from Great product wish it came in a bigger size This product is great my son was only a week early but we have had major issues with him gaining weight. At 4 months old he was only 10 pounds and way off the growth chart. His doctor recommended this formula because of the higher calories. He has had such great weight gain since being on this formula. The only downside is their is only one size of can I wish it would come in a bigger size because we go through it slot. And coupons would be awesome! But I absolutely love this formula for my son and I would definitely recommend it!!!!
Date published: 2017-04-12
Rated 4 out of 5 by from Gassy and small quantities but worth it I have a preemie who was born at 26 weeks. We feed him breastmilk fortified with neosure in his bottles per the neonatologist at the NICU. He was first started on Neosure in the NICU when they were preparing for him to come home after a 3 month NICU stay. Unfortunately, because of the price and only available in the small can I can't afford to fortify every bottle of the day but the majority are. I notice that the fortified with neosure bottles produce a significant discomfort from gas afterwords. At one point we were exclusively breastfeeding but he fell off his curve so he is back to fortified so I know it makes a really big difference! Bigger containers and coupons would be great!
Date published: 2017-04-08
Rated 4 out of 5 by from Great but watch for gas My daughter was in the nicu for about 3 weeks. She was 7 weeks early. The hospital recommended I give her 2 Neosure bottles a day for several months. I have been noticing that the Neosure bottles makes her pretty gassy. She will cry, arch her back, pass gas, and spit up. She also isn't having regularl bowel movements m now which adds to the discomfort.
Date published: 2017-04-05
Rated 5 out of 5 by from Success for our twins Our boy/girl twins were born at 32 weeks and stayed in NICU for three weeks one day. Baby Girl weighed 3lbs 10oz and Baby Boy weighed 3lbs 7oz. NICU supplemented our Twins with Neosure to help them get the extra calories and vitamins they needed to gain weight and develop. We have continued to use Neosure for the last 3 days out of the NICU and they are at 5lbs 3oz now and our pedi said they are doing amazing and to continue with the Similac products. Highly recommend but can be pricey.
Date published: 2017-03-18
Rated 5 out of 5 by from Perfect for preemies My son was born at 27 weeks. He was 2lbs 15". He was started on Neosure in the NICU and we continued it at home. He will only drink the pre-made formula, not the powder mix. He is now 5 months old and weighs 12.5 lbs and is 24" thanks to the vitamins and minerals from the Neosure. His drs are so pleased at his healthy gains in such a short time! The only downside is that he has had a difficult time moving his bowels and he gets very gassy some days. Overall, I would recommend this product to every preemie mom.
Date published: 2017-03-16
Rated 4 out of 5 by from Helping my baby grow My daughter was born at only 28 weeks. Once she was old enough to eat by mouth they changed her diet from fortified breastmilk to pure breastmilk and two feedings of neosure a day. It's helping her gain and keep weight while my breastmilk supply catches up to her needs. I've noticed that it's best to only give her neosure early in the Morning because it causes her to be so gassy and uncomfortable that she won't sleep without being pressed up against my chest. I've also notices it makes it harder for her to pass a bowel movement. I'm going to try splitting up when I give it her instead of it being consecutive feedings and see if that helps. Also the formula is super expensive. Of Your baby needs it due to being a preemie ask your doctor to submit a request to your health insurance. Some will cover the cost. WIC also covers the cost if it is prescribed and health insurance won't cover it.
Date published: 2017-03-14
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