Similac Pro-Total Comfort*

Our most gentle formula with 2’-FL HMO for immune support.

Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

Similac® Pro‐Total Comfort Similac It All adds Up

Similac® Pro‐Total Comfort All in One Day


Switching formulas due to a baby’s sensitive tummy can be overwhelming. At Similac®, we promise to support you on your journey of nourishing your baby and her unique nutrition needs.

The Similac Pro-Total Comfort Difference

  • Our most gentle formula with 2’-FL HMO for immune support and our unique blend of DHA and Lutein for brain and eye development
  • 1 Day—less crying, less fussiness, and less gas§
  • Partially hydrolyzed protein for easy digestion
  • No artificial growth hormonesǁ
  • Makes 4 more 6-fl-oz bottles vs Enfamil NeuroPro Gentlease®¶

See the difference for yourself in our new video.

Gentle formula with partially hydrolyzed protein

Similac Pro-Total Comfort is the first gentle formula with partially hydrolyzed protein and 2’-FL Human Milk Oligosaccharide (HMO),# an immune-nourishing prebiotic like that found** in breast milk. HMOs feed good bacteria in the gut, where 70% of the immune system exists. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant than ever before.


Parents reported a significant reduction in fussiness, gassiness, and crying after just 1 day of feeding.

Designed for delicate tummies

Similac Pro-Total Comfort with 2’FL HMO is an easy-to-digest, gentle formula that’s designed for delicate tummies. It’s a good choice if your child has difficulty tolerating other milk-based formulas.

Exclusive blend of nutrients

Our exclusive blend has DHA, Lutein, and Vitamin E—important ingredients found in breast milk. DHA supports brain development, Lutein supports eye health, and Vitamin E is an important nutrient that supports developing cells.

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* Not for infants or children with galactosemia.
After switching to Pro-Total Comfort.
§ Parents reported‡ a significant reduction in fussiness, gassiness, and crying after 1 day.
ǁ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
Similac Pro-Total Comfort 1.41-lb pack vs Enfamil NeuroPro Gentlease 1.25-lb pack.
# Not from human milk.
** At significant levels.
Enfamil NeuroPro Gentlease is not a registered trademark of Abbott Laboratories.

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Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

Similac® Pro‐Total Comfort Similac It All adds Up

Similac® Pro‐Total Comfort All in One Day


Nutrition Information

Powder / 1.45 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac Advance Stage 1


What is the difference between Similac Pro-Total Comfort vs Similac Pro-Sensitive®?

Similac Pro-Sensitive has intact milk protein while Similac Pro-Total Comfort has 100% whey protein that is partially hydrolyzed as an alternative to standard intact-protein, milk-based formulas.

What’s the difference between Similac Pro‐Advance®, Similac Pro‐Sensitive, Similac Pro-Total Comfort, and other Similac baby formulas?

Similac Pro‐Advance is our closest formula to breast milk. Similac Pro‐Advance, Similac Pro‐Sensitive and Similac Pro-Total Comfort now have 2’-FL HMO (Human Milk Oligosaccharide*), a unique immune-nourishing prebiotic. Other Similac baby formulas also provide complete nutrition for babies, but it’s up to parents, along with their doctor, to choose which formula to feed their baby.

* Not from human milk.

What does Similac Pro-Total Comfort help with?

Similac Pro-Total Comfort with 2’-FL HMO is an easy-to-digest, gentle baby formula that’s designed for babies who have difficulty tolerating other milk-based formulas.


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Similac® Pro-Total Comfort Reviews

Rated 5 out of 5 by from This is the best worked great for my baby Works great fills my baby up and way less fussy he dont have much gas any more either works great
Date published: 2019-10-08
Rated 1 out of 5 by from Smelly feces and painful flatuence We have tried advanced, soy, and total comfort. My son appeared to be allergic to soy due to the bumps around his mouth and neck. The Soy and total comfort gave my 1 month old loud flatulence with a rotten egg Odor. The total comfort also made my baby shriek with gas pains and had dark green feces. No amount of gas drops helped. He is now on pro sensitive. He still has gas but at least it’s not as painful for him. The color of his feces is now a yellowish orange color and his feces doesn’t smell like rotten eggs anymore. Maybe he’s allergic to Soy and Whey?
Date published: 2019-10-08
Rated 2 out of 5 by from Explosive stinky poop I used this formula roughly three months. Finally threw in the towel when she farted herself awake forcefully then cried like it hurt her. To start, this formula takes forever to shake/dissolve. If you don’t take the extra time, it will leave little clumps. When she pooped, it was brown green and explosive. I mean, out the back, in car seat in a puddle. Almost every poop was explosive I could hear it. No fun cleaning poop goop when your running errands. The smell was also strong and awful. And poop doesn’t scare me. That alone is stressful enough. Stripping your baby down in bathrooms, scrubbing out carrier on trips constantly is no fun. Puddles seriously. Also. This doesn’t come in pre made which I started to need in the middle of the night. Trying to shake this properly while your fussy baby waits was terrible. She started farting a lot more too when I used formula more than breastfeeding. I have now switched to sensitive in the orange container and her poop is not foul, thicker, and light peanut butter brown yellow like it should be. It’s only been three days in sensitive but much better results already. And sensitive has pre made bottles for travel.
Date published: 2019-10-04
Rated 4 out of 5 by from This product is ths best, but some difficulties We tried different kind of similac but this is the one very good our child's belly. After we using this never spits up, no gas problems. But only one issue in 2lb pack. Lid has a same like 1lb pack lid, need to be strong lid for big pack. Because very difficult to handling.
Date published: 2019-09-30
Rated 3 out of 5 by from Strong cheese smell and taste This has a funky smell to it somewhat like cheese as well as the taste. I’m not sure it’s supposed to smell that way I stopped using it. She also seems to be a bit more fussy and still very gassy.
Date published: 2019-09-27
Rated 5 out of 5 by from Your product works well for my grandaugher We help out with our first granddaughter, she was on different formula's and had different reactions, we switched to the Similac Pro- Total Comfort and it seemed like the issues went away, we are pleased with this product, my granddaughter seems to react to it nicely. Thank You
Date published: 2019-09-25
Rated 5 out of 5 by from Less constipation, gas, and formula doesnt stink as bad As soon as I started transitioning him on total comfort, he started having more normal and easier bowel movements. He became happier in the afternoons, slept better, and ate less. I wish this had been around when my first son was born. I wish I could find it in the 8oz ready made bottles. Those are convenient for keeping in my diaper bag for backup bottles in case I don't pack enough.
Date published: 2019-09-25
Rated 1 out of 5 by from My baby got sick This product is horrible, I have tried other formulas but this made my baby sick, parents be careful the dust does not dissolve completely and that is ingested by babies causing stomach pain and discomfort. additionally I tried it and it tastes horrible
Date published: 2019-09-18
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