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Similac Pro-Total Comfort*

Our most gentle formula with 2’-FL HMO for immune support.

Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

NoPalmOil-Video-1 No Palm Oil/Palm Olein Oil

NoPalmOil-Video-1 Similac It All adds Up

NoPalmOil-Video-1 All in One Day


Switching formulas due to a baby’s sensitive tummy can be overwhelming. At Similac®, we promise to support you on your journey of nourishing your baby and her unique nutrition needs.

The Similac Pro-Total Comfort Difference

  • Our most gentle formula with 2’-FL HMO for immune support and our unique blend of DHA and Lutein for brain and eye development
  • 1 Day—less crying, less fussiness, and less gas§
  • Partially hydrolyzed protein for easy digestion
  • No artificial growth hormonesǁ
  • Makes 4 more 6-fl-oz bottles vs Enfamil NeuroPro Gentlease®¶

See the difference for yourself in our new video.

Gentle formula with partially hydrolyzed protein

Similac Pro-Total Comfort is the first gentle formula with partially hydrolyzed protein and 2’-FL Human Milk Oligosaccharide (HMO),# an immune-nourishing prebiotic like that found** in breast milk. HMOs feed good bacteria in the gut, where 70% of the immune system exists. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant than ever before.


Parents reported a significant reduction in fussiness, gassiness, and crying after just 1 day of feeding.

Designed for delicate tummies

Similac Pro-Total Comfort with 2’FL HMO is an easy-to-digest, gentle formula that’s designed for delicate tummies. It’s a good choice if your child has difficulty tolerating other milk-based formulas.

Exclusive blend of nutrients

Our exclusive blend has DHA, Lutein, and Vitamin E—important ingredients found in breast milk. DHA supports brain development, Lutein supports eye health, and Vitamin E is an important nutrient that supports developing cells.

For More Support and Information, Join Similac® StrongMoms®

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* Not for infants or children with galactosemia.
After switching to Pro-Total Comfort.
§ Parents reported‡ a significant reduction in fussiness, gassiness, and crying after 1 day.
ǁ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
Similac Pro-Total Comfort 1.41-lb pack vs Enfamil NeuroPro Gentlease 1.25-lb pack.
# Not from human milk.
** At significant levels.
Enfamil NeuroPro Gentlease is not a registered trademark of Abbott Laboratories.

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Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

NoPalmOil-Video-1 No Palm Oil/Palm Olein Oil

NoPalmOil-Video-1 Similac It All adds Up

NoPalmOil-Video-1 All in One Day


Nutrition Information

Powder / 1.45 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac Advance Stage 1


What is the difference between Similac Pro-Total Comfort vs Similac Pro-Sensitive®?

Similac Pro-Sensitive has intact milk protein while Similac Pro-Total Comfort has 100% whey protein that is partially hydrolyzed as an alternative to standard intact-protein, milk-based formulas.

What’s the difference between Similac Pro‐Advance®, Similac Pro‐Sensitive, Similac Pro-Total Comfort, and other Similac baby formulas?

Similac Pro‐Advance is our closest formula to breast milk. Similac Pro‐Advance, Similac Pro‐Sensitive and Similac Pro-Total Comfort now have 2’-FL HMO (Human Milk Oligosaccharide*), a unique immune-nourishing prebiotic. Other Similac baby formulas also provide complete nutrition for babies, but it’s up to parents, along with their doctor, to choose which formula to feed their baby.

* Not from human milk.

What does Similac Pro-Total Comfort help with?

Similac Pro-Total Comfort with 2’-FL HMO is an easy-to-digest, gentle baby formula that’s designed for babies who have difficulty tolerating other milk-based formulas.


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Similac® Pro-Total Comfort Reviews

Rated 4 out of 5 by from Great formula for sensitive tummies Great for babies that are intolerant for other milk formulas I totally recommend
Date published: 2020-04-04
Rated 4 out of 5 by from Works great wish there was a ready made option! We love this product and it does well for our son who had very bad gas issues. My only complaint is I wish it came in the large ready mix bottle. We were able to get several of the 2 oz ready mix bottles from the hospital and those a great for when we are away from home and he needs a feeding. We had hoped we could provide our daycare provider with a ready made bottle but I haven't been able to find this type available.
Date published: 2020-04-01
Rated 5 out of 5 by from Happy Baby, Happy Momma! We struggled with fussiness, gas, and constipation. We tired Pro-Advance then Sensitive and nothing! The thought of us having to help our baby have a BM was starting to worry me. I kept thinking he was getting dependent on us. After 24 hours on this formula, we have a whole different baby!! We noticed he wasn't fussy, while feeding he wasn't gassy as usual, and he already has had 2 dirty diapers with no help from us!! Strongly recommend this formula if your baby is experiencing any of the symptoms described above!! This formula is really a game changer, and so far baby enjoys it!! Happy baby, Happy momma!!!
Date published: 2020-03-11
Rated 5 out of 5 by from Game changer! We changed to total comfort and went from literally never sleeping to sleeping 6 hour stretches at night and taking naps during the day! This formula changed all of our lives for the better and we have a much happier baby! He never had gas issues but we could tell he was uncomfortable so we made the switch and after the first day we saw a huge improvement!
Date published: 2020-02-13
Rated 4 out of 5 by from Worked great for my baby!! At first my baby was on similac advance & when my baby was about 4 days old he screamed & cried for hours due to gas and belly pain so I switched him to similac pro total comfort & within a day & a half he was a completely different baby!! He still gets occasional gas here & there but nothing like he used too! I would highly recommend!
Date published: 2020-02-10
Rated 5 out of 5 by from I love this product for my baby!!! The formula is not too thick. It doesn’t leave any chunky residue in the bottle. It blends very well. My baby seems very happy with this product. She smiles now before every bottle!!!!
Date published: 2020-02-09
Rated 5 out of 5 by from Happy baby & happy parents My son has been on this for two weeks and after a couple feedings I noticed he wasn’t uncomfortable and crying like he was with other formulas. He poops more frequently and isn’t as gassy.
Date published: 2020-02-09
Rated 1 out of 5 by from Horrible discomfort, awful gas and uncomfortable baby This is the second Similac formula we have tried for my infant son, who is now two weeks old. I started him off with pro sensitive because that’s what the hospital had us using during our stay when he was born and I continued to supplement with it when we got home. However something changed and he began to experience horrible constipation and was straining to have a bowel movement if any at all. On the recommendation of our pediatrician I switched him to pro total comfort to see if it would help him. In the beginning it seemed to help him but after a few days he’s been worse. He can’t sleep due to his discomfort, he has awful gas that smells like a bowel movement and is non stop, constant straining, spit ups that come out his nose and mouth, gas that scars him out his sleep and he cries, he’s up all night, he’s choked in his sleep and spit up. The bowl movements are a watery dark green color and smell awful. I would not recommend this product!! I will be changing his formula for the third time now! If the next formula doesn’t help or improve how he’s feeling I will not be using Similac products EVER again and I for sure won’t be recommending them. It so heartbreaking to see your child suffer, and it’s completely unfair. I read the reviews on how people’s children were experiencing the same issues and ignored them and decided to use this product, I honestly regret that decision now.
Date published: 2020-01-26
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