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Similac Pro-Total Comfort*

Our most gentle formula with 2’-FL HMO for immune support.

Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

similac-immunity-OLV.jpg Similac Infant Formula for Immune Support

NoPalmOil-Video-1 No Palm Oil/Palm Olein Oil

NoPalmOil-Video-1 Similac It All adds Up

NoPalmOil-Video-1 All in One Day


Switching formulas due to a baby’s sensitive tummy can be overwhelming. At Similac®, we promise to support you on your journey of nourishing your baby and her unique nutrition needs.

The Similac Pro-Total Comfort Difference

  • Our most gentle formula with 2’-FL HMO for immune support and our unique blend of DHA and Lutein for brain and eye development
  • Parents reported a significant reduction in fussiness, gassiness, and crying after just 1 day of feeding
  • Partially hydrolyzed protein for easy digestion
  • No artificial growth hormonesǁ
  • Makes 4 more 6-fl-oz bottles vs Enfamil NeuroPro Gentlease®¶
  • Gentle for supplementing

See the difference for yourself in our new video.

Gentle formula with partially hydrolyzed protein

Similac Pro-Total Comfort is the first gentle formula with partially hydrolyzed protein and 2’-FL Human Milk Oligosaccharide (HMO),# an immune-nourishing prebiotic like that found** in breast milk. HMOs feed good bacteria in the gut, where 70% of the immune system exists. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant than ever before.


Designed for delicate tummies

Similac Pro-Total Comfort with 2’FL HMO is an easy-to-digest, gentle formula that’s designed for delicate tummies. It’s a good choice if your child has difficulty tolerating other milk-based formulas.

Exclusive blend of nutrients

Our exclusive blend has DHA, Lutein, and Vitamin E—important ingredients found in breast milk. DHA supports brain development, Lutein supports eye health, and Vitamin E is an important nutrient that supports developing cells.

For More Support and Information, Join Similac® StrongMoms®

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* Not for infants or children with galactosemia.
After switching to Pro-Total Comfort.
ǁ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
Similac Pro-Total Comfort 1.41-lb pack vs Enfamil NeuroPro Gentlease 1.25-lb pack.
# Not from human milk.
** At significant levels.
Enfamil NeuroPro Gentlease is not a registered trademark of Abbott Laboratories.

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Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

similac-immunity-OLV.jpg Similac Infant Formula for Immune Support

NoPalmOil-Video-1 No Palm Oil/Palm Olein Oil

NoPalmOil-Video-1 Similac It All adds Up

NoPalmOil-Video-1 All in One Day


Nutrition Information

Powder / 1.45 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac Advance Stage 1


What is the difference between Similac Pro-Total Comfort vs Similac Pro-Sensitive®?

Similac Pro-Sensitive has intact milk protein while Similac Pro-Total Comfort has 100% whey protein that is partially hydrolyzed as an alternative to standard intact-protein, milk-based formulas.

What’s the difference between Similac Pro‐Advance®, Similac Pro‐Sensitive, Similac Pro-Total Comfort, and other Similac baby formulas?

Similac Pro‐Advance is our closest formula to breast milk. Similac Pro‐Advance, Similac Pro‐Sensitive and Similac Pro-Total Comfort now have 2’-FL HMO (Human Milk Oligosaccharide*), a unique immune-nourishing prebiotic. Other Similac baby formulas also provide complete nutrition for babies, but it’s up to parents, along with their doctor, to choose which formula to feed their baby.

* Not from human milk.

What does Similac Pro-Total Comfort help with?

Similac Pro-Total Comfort with 2’-FL HMO is an easy-to-digest, gentle baby formula that’s designed for babies who have difficulty tolerating other milk-based formulas.


New Moms

Join today. Get the promise of Similac® StrongMoms® Rewards and:
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  • Information about your baby’s milestones
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Similac® Pro-Total Comfort Reviews

Rated 5 out of 5 by from Great for my baby girl! My daughter was a super gassy and colicky baby, talked to her doctor and decided to try out this product . I IMMEDIATELY noticed a difference. Completely different baby ! So glad she’s finally feeling better. It’s been a miracle formula.
Date published: 2020-09-19
Rated 5 out of 5 by from Stomach issues lessoned with this product My grandson was a premi and he had lots of stomach issues. This formula helped him so much. We didnt have crying after bottles because it was easy on his digestive track. Love it highly recommend it
Date published: 2020-09-16
Rated 1 out of 5 by from Made my baby bloated and gassy I received the 3 samples, the regular one, sensitive ones and this comfort one. The regular one my baby drank the whole sample and he seemed fine. then I switched over to the sensitive one and went through that whole sample with no issue. Then I switched to this pro comfort one and big mistake! He’s constantly farting and is really bloated. 4 out of the last 6 feedings, he threw up. Thought this was supposed to be the most sensitive of the three but it seems to be the worst of the three in terms of discomfort. I’ll probably just end up buying the regular or sensitive ones.
Date published: 2020-09-07
Rated 5 out of 5 by from Worked well My friend needed some formula to supplement. I had this on hand and gave it to her to try since my kids are a bit older and no longer need formula. She said that it worked well. Her baby had no problems whatsoever.
Date published: 2020-09-03
Rated 5 out of 5 by from Miracle Formula My grandson has just turned 2 months old. He had previously been on Similac Pro Sensitive and Pro Advance and he was constantly crying for hours In the evening and nothing would console him. My daughter was always upset and feeling like a failure. I started googling “crying and fussiness“ and came across issues with sensitivities or allergies to formula. Up pops Pro Total Comfort and I liked what I was reading so I bought her a couple packs of the pre-made 2 fluid Ounce bottles to try. This was last Thursday and here it is Tuesday and he has been a different baby ever since! He eats, has his diaper changed and is a most pleasant baby and goes down easy for naps and bedtime. He is all smiles and cooing now and my daughter is one happy mama. Thank you Similac for creating this new formula. It is a Godsend!
Date published: 2020-09-02
Rated 5 out of 5 by from Wonderful on my babies belly! With me being lactose intolerant we weren't sure how my daughter would react. We tried the Pro-Advanced and she would scream due to colic & constipation. The Pro-Sensitive seemed to help a little better but just wasn't doing the trick. As soon as we switched to the Pro-Total Comfort she was a whole new baby! No longer colicky & poops without problems. Pro-Total Comfort is the best, thank you Similac!!!!!
Date published: 2020-08-31
Rated 4 out of 5 by from This product is okay. My son is 100% breastfed since he was born but I am tryingto wean him off I have tried the sinilac pro sensitive and that made him constipated and he used to scream and cry because he couldn't poop than I switched to similac alimentum powder and the smell is so bad he wouldnt dare drink it but he did drink the ready to feed.I than tried this and he makes bowel movements regularly just wish this came ready to feed as well !! I would love to see the ready to feed happen :)
Date published: 2020-08-24
Rated 1 out of 5 by from Doesn't go for my baby at all. My baby has been fed Similac pro advance and he seems like still have digesting issue so I tried this one. Then my baby got strange stool, greenish black color and diahrrea-like watery poop. Besides, he had rashes all over his face , especially his forehead while he was okay when he had pro-advance. In every aspect of it, don't buy it if u have sensitive baby. I mean, I thought it was for sensitive tummy baby but then it got my baby into worse situation. I don't like odor of it either. I usually don't leave a bad review but I should have, because it's for babies. It just doesn't fit for my baby's tummy. I switched to pro- advance again and he's doing fine so far though it takes longer time to digest after feeding.
Date published: 2020-08-20
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