Similac Pro-Total Comfort*

Our most gentle formula with 2’-FL HMO for immune support.

Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

Similac® Pro‐Total Comfort Similac It All adds Up

Similac® Pro‐Total Comfort All in One Day


Switching formulas due to a baby’s sensitive tummy can be overwhelming. At Similac®, we promise to support you on your journey of nourishing your baby and her unique nutrition needs.

The Similac Pro-Total Comfort Difference

  • Our most gentle formula with 2’-FL HMO for immune support and our unique blend of DHA and Lutein for brain and eye development
  • 1 Day—less crying, less fussiness, and less gas§
  • Partially hydrolyzed protein for easy digestion
  • No artificial growth hormonesǁ
  • Makes 4 more 6-fl-oz bottles vs Enfamil NeuroPro Gentlease®¶

See the difference for yourself in our new video.

Gentle formula with partially hydrolyzed protein

Similac Pro-Total Comfort is the first gentle formula with partially hydrolyzed protein and 2’-FL Human Milk Oligosaccharide (HMO),# an immune-nourishing prebiotic like that found** in breast milk. HMOs feed good bacteria in the gut, where 70% of the immune system exists. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant than ever before.


Parents reported a significant reduction in fussiness, gassiness, and crying after just 1 day of feeding.

Designed for delicate tummies

Similac Pro-Total Comfort with 2’FL HMO is an easy-to-digest, gentle formula that’s designed for delicate tummies. It’s a good choice if your child has difficulty tolerating other milk-based formulas.

Exclusive blend of nutrients

Our exclusive blend has DHA, Lutein, and Vitamin E—important ingredients found in breast milk. DHA supports brain development, Lutein supports eye health, and Vitamin E is an important nutrient that supports developing cells.

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* Not for infants or children with galactosemia.
After switching to Pro-Total Comfort.
§ Parents reported‡ a significant reduction in fussiness, gassiness, and crying after 1 day.
ǁ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
Similac Pro-Total Comfort 1.41-lb pack vs Enfamil NeuroPro Gentlease 1.25-lb pack.
# Not from human milk.
** At significant levels.
Enfamil NeuroPro Gentlease is not a registered trademark of Abbott Laboratories.

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Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

Similac® Pro‐Total Comfort Similac It All adds Up

Similac® Pro‐Total Comfort All in One Day


Nutrition Information

Powder / 1.45 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac Advance Stage 1


What is the difference between Similac Pro-Total Comfort vs Similac Pro-Sensitive®?

Similac Pro-Sensitive has intact milk protein while Similac Pro-Total Comfort has 100% whey protein that is partially hydrolyzed as an alternative to standard intact-protein, milk-based formulas.

What’s the difference between Similac Pro‐Advance®, Similac Pro‐Sensitive, Similac Pro-Total Comfort, and other Similac baby formulas?

Similac Pro‐Advance is our closest formula to breast milk. Similac Pro‐Advance, Similac Pro‐Sensitive and Similac Pro-Total Comfort now have 2’-FL HMO (Human Milk Oligosaccharide*), a unique immune-nourishing prebiotic. Other Similac baby formulas also provide complete nutrition for babies, but it’s up to parents, along with their doctor, to choose which formula to feed their baby.

* Not from human milk.

What does Similac Pro-Total Comfort help with?

Similac Pro-Total Comfort with 2’-FL HMO is an easy-to-digest, gentle baby formula that’s designed for babies who have difficulty tolerating other milk-based formulas.


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Similac® Pro-Total Comfort Reviews

Rated 5 out of 5 by from Happier Baby I’m the principle caregiver for my grandson since both his parents work odd hours and sometimes extremely long ones at that. When he was born in July he received enfamil from the hospital however, it left him gassy, fussy and he kept throwing it up. His pediatrician suggested Similac pro-total comfort and he has done very well with it. Our only issue is that it’s costs so much even at stores like Walmart or Publix. We checked the prices on Amazon and for then1 month supply it’s compatible to 6 of the 30% more cans. I used Similac for my son when he was a baby and now we are using it for his son.
Date published: 2020-01-17
Rated 4 out of 5 by from Great supplement to breast milk! We started supplementing with this formula when our little guy was about 7 weeks old or so. No looking back. :) It doesn't smell the best when mixed and I have no issues getting it to mix well as I am a swirler not a shaker when preparing formula. It does make his stools strong smelling and a greenish in color but he is a happy baby overall. Sleeps thru the night and looks forward to.his bottles each day. He is nearly 90% formula fed now. ❤
Date published: 2020-01-17
Rated 1 out of 5 by from This formula wasn’t a good fit for our twins We switched to Similac Pro-total comfort because our pediatrician said it would help our 2month old twins with their gas issues and bowl problems. Sadly that was the exact opposite. We went out and loaded up on 10 containers of formula tried it for a week to give it a fair chance at helping. And all we ended up with was two babies with horrible stomach aches, excessive gas, and sleepless nights.
Date published: 2020-01-15
Rated 5 out of 5 by from cholicy, gassy unbearable baby Our 6 week old has been extremely fussy to the point is was unbearable and made for long sleepless nights. We finally made a Dr. appointment thinking at one point she was not eating because of a sore throat or something. Dr switched us to this formal for her gas and fussiness and because she has been constipated. It has made a night and day difference for us. I know each baby is different, but I am glad we made the change. I just wish Similac would provide the same type of coupons like Enfemil does.
Date published: 2020-01-12
Rated 1 out of 5 by from Baby was gassier and did not tolerate Product was recommended by pediatrician and sample was provided. Baby seemed to be tolerating during the first 24 hours so we bought a big can. 48 hours in baby was pushing bottle away, crying inconsolably, having diarrhea that was a dark green, and having massive spit ups. We switched back to the formula he was using before and we saw drastic improvement. It is a shame that the can will go to waste.
Date published: 2020-01-09
Rated 1 out of 5 by from Made our babies worse! We switched our 7 week old twin girls to pro total comfort because they were having issues with gas and spitting up while on the neosure. After the first feeding with the pro total comfort they were screaming and were obviously very uncomfortable. We said we would try a few more feedings with the pro total comfort to see if they would adjust but it just kept getting worse! They began to have green, runny diarrhea 3-4 times in one day and constant crying in between feedings. Wish I wouldn’t have bought the largest container because now it will probably just go to waste.
Date published: 2020-01-05
Rated 1 out of 5 by from About a week after trying Total Comfort my daughter’s symptoms became worse. Our daughter was switched to Total Comfort after being fussy on Pro-Advance. About a week after drinking Total Comfort her symptoms became worse. Within a 24 hour window she vomited 3 times, throwing up what seemed to be the entire bottle of formula she drank. It even came out of her nose. Her stomach began to gurgle and she was much more fussy. We’re going to try the Sensitive formula. Hopefully that will be better for her to digest. If that doesn’t work, we’ll probably not use Similac any longer.
Date published: 2019-12-26
Rated 5 out of 5 by from Great product My son was constipated when he was in the blue top I switch his milk and first day he was fine now he back his self
Date published: 2019-11-20
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