Similac Pro-Total Comfort*

Our most gentle formula with 2’-FL HMO for immune support.

Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

Similac® Pro‐Total Comfort Similac It All adds Up

Similac® Pro‐Total Comfort All in One Day


Switching formulas due to a baby’s sensitive tummy can be overwhelming. At Similac®, we promise to support you on your journey of nourishing your baby and her unique nutrition needs.

The Similac Pro-Total Comfort Difference

  • Our most gentle formula with 2’-FL HMO for immune support and our unique blend of DHA and Lutein for brain and eye development
  • 1 Day—less crying, less fussiness, and less gas§
  • Partially hydrolyzed protein for easy digestion
  • No artificial growth hormonesǁ
  • Makes 4 more 6-fl-oz bottles vs Enfamil NeuroPro Gentlease®¶

See the difference for yourself in our new video.

Gentle formula with partially hydrolyzed protein

Similac Pro-Total Comfort is the first gentle formula with partially hydrolyzed protein and 2’-FL Human Milk Oligosaccharide (HMO),# an immune-nourishing prebiotic like that found** in breast milk. HMOs feed good bacteria in the gut, where 70% of the immune system exists. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant than ever before.


Parents reported a significant reduction in fussiness, gassiness, and crying after just 1 day of feeding.

Designed for delicate tummies

Similac Pro-Total Comfort with 2’FL HMO is an easy-to-digest, gentle formula that’s designed for delicate tummies. It’s a good choice if your child has difficulty tolerating other milk-based formulas.

Exclusive blend of nutrients

Our exclusive blend has DHA, Lutein, and Vitamin E—important ingredients found in breast milk. DHA supports brain development, Lutein supports eye health, and Vitamin E is an important nutrient that supports developing cells.

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* Not for infants or children with galactosemia.
After switching to Pro-Total Comfort.
§ Parents reported‡ a significant reduction in fussiness, gassiness, and crying after 1 day.
ǁ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
Similac Pro-Total Comfort 1.41-lb pack vs Enfamil NeuroPro Gentlease 1.25-lb pack.
# Not from human milk.
** At significant levels.
Enfamil NeuroPro Gentlease is not a registered trademark of Abbott Laboratories.

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Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

Similac® Pro‐Total Comfort Similac It All adds Up

Similac® Pro‐Total Comfort All in One Day


Nutrition Information

Powder / 1.45 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac Advance Stage 1


What is the difference between Similac Pro-Total Comfort vs Similac Pro-Sensitive®?

Similac Pro-Sensitive has intact milk protein while Similac Pro-Total Comfort has 100% whey protein that is partially hydrolyzed as an alternative to standard intact-protein, milk-based formulas.

What’s the difference between Similac Pro‐Advance®, Similac Pro‐Sensitive, Similac Pro-Total Comfort, and other Similac baby formulas?

Similac Pro‐Advance is our closest formula to breast milk. Similac Pro‐Advance, Similac Pro‐Sensitive and Similac Pro-Total Comfort now have 2’-FL HMO (Human Milk Oligosaccharide*), a unique immune-nourishing prebiotic. Other Similac baby formulas also provide complete nutrition for babies, but it’s up to parents, along with their doctor, to choose which formula to feed their baby.

* Not from human milk.

What does Similac Pro-Total Comfort help with?

Similac Pro-Total Comfort with 2’-FL HMO is an easy-to-digest, gentle baby formula that’s designed for babies who have difficulty tolerating other milk-based formulas.


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Similac® Pro-Total Comfort Reviews

Rated 5 out of 5 by from Great product My son was constipated when he was in the blue top I switch his milk and first day he was fine now he back his self
Date published: 2019-11-20
Rated 5 out of 5 by from Amazing My now 7 week old daughter started as breastfeed in the hospital but after leaving the hospital she started to act and sound like my 6 year old son while drinking my milk so we decided to try Similac pro sensitive and we were doing great till about 3 weeks when her colic set in that is when the gas got really really bad I mean blood curdling screams so not wanting to go completely lactose free I said we will try this after I did all of research if it doesn’t work we will go to alimentum but low and behold within 24 hours of being on pro total comfort and she was a total different baby within a week she was burping and pooping a lot better granted her farts clear the room as well as her poop but we can handle that so by far this had been an awesome formula for my daughter just wish that wic would pick it up since it is virtually the only one of it’s kind
Date published: 2019-11-18
Rated 2 out of 5 by from Not for everyone After using another similac product and having some issues with acid reflux like symptoms, we decided to give this product a chance. At first we started seeing immediate relief, but after five days of use we saw a turn for the worse. • Extremely foul smelling, runny, green bowel movements. • Large and sudden BMs that would result in blowouts if not immediately taken care of • Frequent gas, often smelling like a full BM • Discomforting gas, making it difficult to sleep • Numerous spit ups • Larger feedings due to spit up This product, being whey based, produces a more sudsy mix and requires vigors shaking compared to other similac products due to clumping. I would only recommend using this product if you know your child has irritability to milk similar products and your pediatrician recommends trying something whey based.
Date published: 2019-11-13
Rated 5 out of 5 by from all babies are different my baby 4 months old since she was 3 weeks i been on a mission finding good formula before having to put her on soy and the 1st formula she started on was similac advance and i was giving her half an half formula and breast milk but i had to stop because the milk flow was not enough so the formula became no good at all, then i switched to pro-advance no good, she started with the bad spit up an vomits with gas and pains so we switched to similac spit up and that was no good made it worse, then i tried similac pro sensitive and that was the worst milk of all the pains stopped but the gas got worse and the throws up were really bad throwing up everything all day an night so i switched her last to similac pro total comfort and she doing good no throwing up, no gas, no pain no none of that and i'm hoping it stays that way because am trying not put my baby on soy... but all babies are different some do good with cretin milk that others don't do good with that don't mean don't try it or buy it, just because one milk wasn't good for your child don't mean it will do the same for the next child because this formula did great with my child.. all i do know that u gotta keep trying till u find the right formula
Date published: 2019-11-09
Rated 1 out of 5 by from Made everything worse The baby started choking/gagging in his sleep while on the Pro-Advance so we were told to switch to Pro Total Comfort. Unfortunately, now we not only have a baby that still chokes in his sleep, now he is extra gassy and starting to spit up more. Obviously the claim that this helps is a lie. Really disappointed in Similac products, so far every mom I’ve spoken with has hd nothing but trouble with it.
Date published: 2019-11-08
Rated 1 out of 5 by from Don’t Buy I tried this after my baby kept fussing after another formula. I read these reviews and ignored them being that my Dr recommend it. Boy I wish I would of listened. Not only was my baby extremely gassy and fussy. His poop was dark green and he would cry from constipation and the spot up was constant! Not to meantion that shaking this product was almost impossible to break down the clumps. I’m not a fan and have to switch up something else and have lost all hope in Similac’s products all together at this point.
Date published: 2019-11-05
Rated 3 out of 5 by from Makes my Baby Poop I tried this formula for my newborn and she keeps on pooping and gassy. When I switched to breastmilk my baby seems very calm, no more poop, not gassy. Dissapointed.
Date published: 2019-10-31
Rated 5 out of 5 by from The key to all our problems At first we supplemented with pro advance but my son would projectile vomit after every bottle. The pediatrician gave us samples of this formula and my son stopped vomiting that day! It’s so gentle on his belly. When you make the bottle, you can see it start dissolving as soon as it hits the water. I’m so glad that we found what works for him. It smells better and feels better than other ones we’ve tried.
Date published: 2019-10-22
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