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Similac Pro-Total Comfort

Easy-to-digest, gentle formula with 2’-FL HMO for immune support


The Similac Pro-Total Comfort Difference

  • Our most gentle formula with 2’-FL HMO for immune support
  • 1 Day—less crying, less fussiness, and less gas*
  • Partially hydrolyzed protein for easy digestion
  • No artificial growth hormones
  • Makes 4 more 6-fl-oz bottles vs Enfamil NeuroPro Gentlease®‡

See the difference for yourself in our new video.

Gentle formula with partially hydrolyzed protein

Similac Pro-Total Comfort is the first gentle formula with partially hydrolyzed protein and 2’-FL Human Milk Oligosaccharide (HMO),§ an immune-nourishing prebiotic like that foundǁ in breast milk. HMOs feed good bacteria in the gut, where 70% of the immune system exists. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant than ever before.


Parents reported a significant reduction in fussiness, gassiness, and crying after just 1 day of feeding.

Designed for delicate tummies

Similac Pro-Total Comfort with 2’FL HMO is an easy-to-digest, gentle formula that’s designed for delicate tummies. It’s a good choice if your child has difficulty tolerating other milk-based formulas.

Exclusive blend of nutrients

Our exclusive blend has DHA, Lutein, and Vitamin E—important ingredients found in breast milk. DHA supports brain development, Lutein supports eye health, and Vitamin E is an important nutrient that supports developing cells.



* Parents reported a significant reduction in fussiness, gassiness, and crying after 1 day.
No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
Similac Pro-Total Comfort 1.41-lb pack vs Enfamil NeuroPro Gentlease 1.25-lb pack.
§ Not from human milk.
ǁ At significant levels.
After switching to Pro-Total Comfort.
** Total US infant formula, all outlets as of 3/31/2018, Nielsen data.

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newlook-logo Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

Similac® Pro‐Total Comfort Similac It All adds Up


Nutrition Information

Powder / 1.45 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac Advance Stage 1


What is the difference between Similac Pro-Total Comfort vs Similac Pro-Sensitive™ ?

Similac Pro-Sensitive has intact milk protein while Similac Pro-Total Comfort has 100% whey protein that is partially hydrolyzed as an alternative to standard intact-protein, milk-based formulas.

What’s the difference between Similac Pro‐Advance™, Similac Pro‐Sensitive, Similac Pro-Total Comfort, and other Similac baby formulas?

Similac Pro‐Advance is our closest formula to breast milk. Similac Pro‐Advance, Similac Pro‐Sensitive and Similac Pro-Total Comfort now have 2’-FL HMO (Human Milk Oligosaccharide*), a unique immune-nourishing prebiotic. Other Similac baby formulas also provide complete nutrition for babies, but it’s up to parents, along with their doctor, to choose which formula to feed their baby.

* Not from human milk.

What does Similac Pro-Total Comfort help with?

Similac Pro-Total Comfort with 2’-FL HMO is an easy-to-digest, gentle baby formula that’s designed for babies who have difficulty tolerating other milk-based formulas.


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Similac® Pro-Total Comfort Reviews

Rated 2 out of 5 by from Groaning and straining Tried this after we finished the Pro Sensitive sampler from hosp. With the sensitive, he passed gas no problem. but with this one, he is just uncomfortable and straining for hours like trying to poop. This should be renamed PRO TOTAL DISCOMFORT! I'll be switching back to the Sensitive. I hope Similac will send additional sample tub of the Sensitive. Id recommend it over this kind.
Date published: 2018-10-18
Rated 1 out of 5 by from Not good I bought this formula for my babies to decrease their fussiness and their gas. Well, after 1st day, babies are more fusdy, gassy, I still gave it a try for more days just to end with constipated babies. Very expenaive formula and does not do what it claims it does.
Date published: 2018-10-17
Rated 1 out of 5 by from Vomiting! Total change from old formula My 9 month old was using the old formulation since 2 months old with no issues. We've now had two vomiting episodes with the Pro version, and it's apparent he does not even want to drink it as he is refusing the bottle. Luckily we had the ready to feed 2 oz. bottles of the old formulation and he tolerates that just fine. These are only available on the Abbott website, and they are far more expensive than the powder so we are going to need to find a more permanent solution.
Date published: 2018-10-16
Rated 1 out of 5 by from One small bottle and my baby has bad gas, sleepless and crying and has g Increase gas, went from multiple poops a day to having Nothing since the bottle and it was only two oz of this. She is sleepless and crying with a crazy belly. I wouldn’t recommend. Wish I didn’t spend my money on this.
Date published: 2018-10-14
Rated 3 out of 5 by from The 3rd formula we've tried Nop, helped with the gas and fussiness but this formula made my baby constipated, he went from 6 pooped diapers to 1 in 28 hours, very solid, and of course he was super fussy and crying, straining hard. Thinking of switching to another brand.
Date published: 2018-10-13
Rated 2 out of 5 by from Less gas but more reflux We switched to this formula from the pro-sensitive hoping it would help our daughter with her gas and discomfort. She also struggles with mild reflux so we have to burp her after every ounce and keep her elevated for 30 mins after every feeding. On the pro-sensitive she had no reflux but still severely gassy. Switched to this and the gasiness was better but the reflux severely worse! We are now back on pro-sensitive because gas and discomfort can be easily addressed with gas drops added to every bottle versus fighting reflux, choking from the reflux and restlessness from reflux. Wishing there was something in between that could help both problems.
Date published: 2018-10-12
Rated 5 out of 5 by from Only one my son can have My son seems to be able to only tolerate this formula. Every other one we have tried has hurt his stomach and made him ridiculously gassy and fussy. This one seems to keep him regular and calm. I think it all depends on the kid with formula. All of our bodies are different and different things affect us all differently. But for mine, this stuff rocks! I would love some coupons since the price is so high!
Date published: 2018-10-02
Rated 1 out of 5 by from Made it Worse My baby had gas issues before and I thought Similac Pro-Total Comfort would fix it. NOPE. Baby was fussy, spat up more and became constipated.
Date published: 2018-09-28
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Has your family been affected by Hurricane Michael?

If you or someone you know has been affected, find out how Similac® can help.