Similac Pro-Total Comfort*

Our most gentle formula with 2’-FL HMO for immune support.

Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

Similac® Pro‐Total Comfort Similac It All adds Up

Similac® Pro‐Total Comfort All in One Day


Switching formulas due to a baby’s sensitive tummy can be overwhelming. At Similac®, we promise to support you on your journey of nourishing your baby and her unique nutrition needs.

The Similac Pro-Total Comfort Difference

  • Our most gentle formula with 2’-FL HMO for immune support and our unique blend of DHA and Lutein for brain and eye development
  • 1 Day—less crying, less fussiness, and less gas§
  • Partially hydrolyzed protein for easy digestion
  • No artificial growth hormonesǁ
  • Makes 4 more 6-fl-oz bottles vs Enfamil NeuroPro Gentlease®¶

See the difference for yourself in our new video.

Gentle formula with partially hydrolyzed protein

Similac Pro-Total Comfort is the first gentle formula with partially hydrolyzed protein and 2’-FL Human Milk Oligosaccharide (HMO),# an immune-nourishing prebiotic like that found** in breast milk. HMOs feed good bacteria in the gut, where 70% of the immune system exists. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant than ever before.


Parents reported a significant reduction in fussiness, gassiness, and crying after just 1 day of feeding.

Designed for delicate tummies

Similac Pro-Total Comfort with 2’FL HMO is an easy-to-digest, gentle formula that’s designed for delicate tummies. It’s a good choice if your child has difficulty tolerating other milk-based formulas.

Exclusive blend of nutrients

Our exclusive blend has DHA, Lutein, and Vitamin E—important ingredients found in breast milk. DHA supports brain development, Lutein supports eye health, and Vitamin E is an important nutrient that supports developing cells.

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* Not for infants or children with galactosemia.
After switching to Pro-Total Comfort.
§ Parents reported‡ a significant reduction in fussiness, gassiness, and crying after 1 day.
ǁ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
Similac Pro-Total Comfort 1.41-lb pack vs Enfamil NeuroPro Gentlease 1.25-lb pack.
# Not from human milk.
** At significant levels.
Enfamil NeuroPro Gentlease is not a registered trademark of Abbott Laboratories.

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Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

Similac® Pro‐Total Comfort Similac It All adds Up

Similac® Pro‐Total Comfort All in One Day


Nutrition Information

Powder / 1.45 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac Advance Stage 1


What is the difference between Similac Pro-Total Comfort vs Similac Pro-Sensitive®?

Similac Pro-Sensitive has intact milk protein while Similac Pro-Total Comfort has 100% whey protein that is partially hydrolyzed as an alternative to standard intact-protein, milk-based formulas.

What’s the difference between Similac Pro‐Advance®, Similac Pro‐Sensitive, Similac Pro-Total Comfort, and other Similac baby formulas?

Similac Pro‐Advance is our closest formula to breast milk. Similac Pro‐Advance, Similac Pro‐Sensitive and Similac Pro-Total Comfort now have 2’-FL HMO (Human Milk Oligosaccharide*), a unique immune-nourishing prebiotic. Other Similac baby formulas also provide complete nutrition for babies, but it’s up to parents, along with their doctor, to choose which formula to feed their baby.

* Not from human milk.

What does Similac Pro-Total Comfort help with?

Similac Pro-Total Comfort with 2’-FL HMO is an easy-to-digest, gentle baby formula that’s designed for babies who have difficulty tolerating other milk-based formulas.


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Similac® Pro-Total Comfort Reviews

Rated 2 out of 5 by from Not the best product on the market Unfortunately we tried this not long after my son was diagnosed with a few stomach issues. The pediatrician advised it would be a good formula to try and assist him with the issues we were facing as he had been 4 weeks premature. The formula almost seemed to increase the problems and he began projectile vomiting with the formula. After 6 days of use we discontinued using and switched to a different product with better success. I can’t say I’d recommend this as we didn’t have any of the same issues with any other formulas.
Date published: 2019-08-06
Rated 5 out of 5 by from Breastfeed to Forumla My daughter has been on breastmilk for the first 6 months of her life. Now switching to formula my doctor recommended Similac Pro-Total Comfort. After a few times of her having this we are switched over and she is doing well. No complaints so far.
Date published: 2019-07-23
Rated 1 out of 5 by from Greenish foul smell diarrhea My baby kept having vomiting after feeding pro-advance, so we tried to switch. On the first day, he had foul smell greenish diarrhea. He always had yellow poops until we used this formula. The smell of the formula itself is also bad. Will go back to pro advance or try different brand.
Date published: 2019-07-22
Rated 3 out of 5 by from Baby wouldn't drink it We tried Similac Pro-Total Comfort because a friend of ours said it was the only formula their picky baby would drink. We have a similarly picky baby and had tried several other formulas with no luck. Our 6 month old wouldn't drink the Similac Pro-Total Comfort either but has also not successfully drank any other formulas. She does take a bottle with breast milk, but still no luck with formula.
Date published: 2019-07-20
Rated 5 out of 5 by from Worked wonders for my baby. My baby was having a hard time after switching from breast milk to formula. I tried around 6 formula's that all failed or made his stomach issues worse before I was referred to Pro Total Comfort. This formula made all the difference! I could tell a difference after a few feedings. This formula worked wonders on baby and helped so much! I highly recommend this if you have a baby with a sensitive tummy!
Date published: 2019-07-17
Rated 1 out of 5 by from Messed her little tummy up bad! We decided to try the total comfort because it seemed to cover everything we were dealing with (fussing, gas, etc.), but after the first day (honestly after just a few bottles), my little one was having bad bubbly stomach cramps and diarrhea. We switched to the pro sensitive and had a much happier baby girl.
Date published: 2019-07-15
Rated 2 out of 5 by from Hungry all the time I was feeding similac pro advance and noticed my baby was gassy and extra fussy so I switched to total comfort. He’s been on it for about 3 weeks. At first his gas improved but he always acted like he was starving an hour or two later. Now that he’s 7 weeks old he’s eating 5 oz and he’s back to being really gassy and not sleeping well because of it. It also makes him have liquid stool that is really smelly.
Date published: 2019-07-15
Rated 5 out of 5 by from Helps with constipation I’m going to start of by saying this formula it’s not for every infant . If you take time to read the information giving it states that this formula it’s not for recommend for infants with galactosemia . Galactosemia basically means galactose + blood, accumulation of galactose in blood. Now this formula it’s perfect for those who doesn’t have that condition. Specially if your infant it suffering of constipation . My child was taking the Similac Pro-Sensitive but after a week and a half he started getting constipated so I decided to switch to the Similac Total-Comfort, wanted to see what it did if it reduced the gassing and helped in anyways . Now unfortunately the milk does have a funky smell but it does it’s job . It reduces gasses so the baby don’t have pain and it really helps with constipation with just one bottle . Many people are complaining about the smell and how it don’t dissolve as well .And as a mom I’ll be more worried about the reaction my baby has than what it actually look and smell like . Nothing it’s perfect , if it was the formula who desdoble well wouldn’t constipate the child.
Date published: 2019-07-13
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