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Similac Pro-Total Comfort*

Our most gentle formula with 2’-FL HMO for immune support.

Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

similac-immunity-OLV.jpg Similac Infant Formula for Immune Support

NoPalmOil-Video-1 No Palm Oil/Palm Olein Oil

NoPalmOil-Video-1 Similac It All adds Up

NoPalmOil-Video-1 All in One Day


Switching formulas due to a baby’s sensitive tummy can be overwhelming. At Similac®, we promise to support you on your journey of nourishing your baby and her unique nutrition needs.

The Similac Pro-Total Comfort Difference

  • Our most gentle formula with 2’-FL HMO for immune support and our unique blend of DHA and Lutein for brain and eye development
  • Parents reported a significant reduction in fussiness, gassiness, and crying after just 1 day of feeding
  • Partially hydrolyzed protein for easy digestion
  • No artificial growth hormonesǁ
  • Makes 4 more 6-fl-oz bottles vs Enfamil NeuroPro Gentlease®¶
  • Gentle for supplementing

See the difference for yourself in our new video.

Gentle formula with partially hydrolyzed protein

Similac Pro-Total Comfort is the first gentle formula with partially hydrolyzed protein and 2’-FL Human Milk Oligosaccharide (HMO),# an immune-nourishing prebiotic like that found** in breast milk. HMOs feed good bacteria in the gut, where 70% of the immune system exists. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant than ever before.


Designed for delicate tummies

Similac Pro-Total Comfort with 2’FL HMO is an easy-to-digest, gentle formula that’s designed for delicate tummies. It’s a good choice if your child has difficulty tolerating other milk-based formulas.

Exclusive blend of nutrients

Our exclusive blend has DHA, Lutein, and Vitamin E—important ingredients found in breast milk. DHA supports brain development, Lutein supports eye health, and Vitamin E is an important nutrient that supports developing cells.

For More Support and Information, Join Similac® StrongMoms®

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* Not for infants or children with galactosemia.
After switching to Pro-Total Comfort.
ǁ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
Similac Pro-Total Comfort 1.41-lb pack vs Enfamil NeuroPro Gentlease 1.25-lb pack.
# Not from human milk.
** At significant levels.
Enfamil NeuroPro Gentlease is not a registered trademark of Abbott Laboratories.

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Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder

similac-immunity-OLV.jpg Similac Infant Formula for Immune Support

NoPalmOil-Video-1 No Palm Oil/Palm Olein Oil

NoPalmOil-Video-1 Similac It All adds Up

NoPalmOil-Video-1 All in One Day


Nutrition Information

Powder / 1.45 lb

Serving size: 100 Cal (5 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac Advance Stage 1


What is the difference between Similac Pro-Total Comfort vs Similac Pro-Sensitive®?

Similac Pro-Sensitive has intact milk protein while Similac Pro-Total Comfort has 100% whey protein that is partially hydrolyzed as an alternative to standard intact-protein, milk-based formulas.

What’s the difference between Similac Pro‐Advance®, Similac Pro‐Sensitive, Similac Pro-Total Comfort, and other Similac baby formulas?

Similac Pro‐Advance is our closest formula to breast milk. Similac Pro‐Advance, Similac Pro‐Sensitive and Similac Pro-Total Comfort now have 2’-FL HMO (Human Milk Oligosaccharide*), a unique immune-nourishing prebiotic. Other Similac baby formulas also provide complete nutrition for babies, but it’s up to parents, along with their doctor, to choose which formula to feed their baby.

* Not from human milk.

What does Similac Pro-Total Comfort help with?

Similac Pro-Total Comfort with 2’-FL HMO is an easy-to-digest, gentle baby formula that’s designed for babies who have difficulty tolerating other milk-based formulas.


New Moms

Join today. Get the promise of Similac® StrongMoms® Rewards and:
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  • Information about your baby’s milestones
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Similac® Pro-Total Comfort Reviews

Rated 1 out of 5 by from NOT GOOD FOR MY BABY We tried similac pro advanced but it was causing him so much discomfort baby and I could not sleep. So we switched to similac pro sensitive which was better but he was still uncomfortable so we tried pro total comfort. We only gave him two feedings and he spit it all up both times! I was so disappointed. I have always loved similac since I used it in the past with my daughter who is now 4 yo. Now I have a practically new can of formula that I can't use since we decided to go back to the pro sensitive and give it another try.
Date published: 2020-11-22
Rated 3 out of 5 by from This product may work well for some but not my son. My son was first on the Pro Advance. The doctor quickly switched him to Pro Sensitive because the Pro Advance was curdling back up in his mouth. He continued to be very fussy with apparent colic with bouts of crying throughout the day. I ended up calling and asking about trying the Pro Total Comfort after several bad nights of no sleep. He is a little better but still cries a good bit. He has a lot of terrible gas and major green blowouts on it.
Date published: 2020-11-12
Rated 5 out of 5 by from Great product!! I have tried the competitor brand with my first son and I had so many issues with gases, crying and colicky, Now with my second baby I decide to try Similac.I started with pro- sensitive and switched to pro-total confort now , and i can tell you it was the best decision I took to try Similac brand !!! , no fussiness, no gases, no crying !! The best !! Thank you similac
Date published: 2020-11-03
Rated 5 out of 5 by from Best formula! I recently switched my 10 wk old from breast milk to formula because I'm going back to work and pumping isn't working out. This formula helped make the transition very smooth for my little one. She was colicky and I swear this formula stopped all issues within 48 hours. She's not as gassy and much calmer. I'm so thankful I made this switch!
Date published: 2020-10-19
Rated 5 out of 5 by from Great Formula My baby boy tried two other similac formula before our doctor recommended this one. We instantly saw a difference. His fussiness went away and so did his colic. To see the relief in his eyes was pure bliss. He loves this formula and so do we as parents. It’s helped him so much.
Date published: 2020-10-08
Rated 5 out of 5 by from My baby boy is so happy! I tried the regular, and sensitive formula from similac and my little boy was not having it! I was so stressed and felt so bad for him and the gas pains he kept having! As a brand new mom, I had no idea what to do. I decided to try this formula before soy, and I'm so glad I did! Not even 24hrs and he is already feeling better! Similac is awesome!❤
Date published: 2020-10-07
Rated 5 out of 5 by from Works for my little one Started on Similac pro-advance and my newborn had the worst tummy pains. We then tried Similac pro sensitive and it helped a little bit but she still had terrible nights with very bad gas she had trouble passing. Finally we tried this and it made a huge difference in only a few bottles.
Date published: 2020-10-04
Rated 5 out of 5 by from Results within the first day My then 2 week old baby girl was having problems with the similac advance, we switched her to the similac sensitive and it reduced some of the gas and fussiness, but she still wasn’t herself. So, we tried the pro total comfort and I noticed results within the first couple of feedings. I got my easy going, laid back baby girl back. She is now a month old and we have had no issues. She’s her normal little self again. I am very pleased with this product and would recommend it to anyone.
Date published: 2020-10-01
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