Similac Pro-Total Comfort™*

Easy-to-digest, gentle formula with 2’-FL HMO for immune support


Gentle formula with partially hydrolyzed protein

Similac Pro-Total Comfort is the first gentle formula with partially hydrolyzed protein and 2’-FL Human Milk Oligosaccharide (HMO), an immune-nourishing prebiotic like that found in breast milk. HMOs feed good bacteria in the gut, where 70% of the immune system exists. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant than ever before.


Parents reported§ a significant reduction in fussiness, gassiness, and crying after just 1 day of feeding.

Designed for delicate tummies

Similac Pro-Total Comfort with 2’FL HMO is an easy-to-digest, gentle formula that’s designed for delicate tummies. It’s a good choice if your child has difficulty tolerating other milk-based formulas.

Exclusive blend of nutrients

Our exclusive blend has DHA, Lutein, and Vitamin E—important ingredients found in breast milk. DHA supports brain development, Lutein supports eye health, and Vitamin E is an important nutrient that supports developing cells.


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* Not for infants or children with galactosemia.
Not from human milk.
At significant levels.
§ After switching to Pro-Total Comfort.
|| Total US infant formula, all outsets as of 3/31/2018, Nielsen data.

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newlook-logo Similac® Pro-Total Comfort™ Easy-to-digest Infant Formula

Available In:

Similac® Pro‐Total Comfort 1.41-lb Powder


Nutrition Information

Powder / 1.45 lb

Serving size: 100 Cal (5.3 fl oz, prepared as directed)

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac Advance Stage 1
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Similac® Pro-Total Comfort Reviews

Rated 1 out of 5 by from Such a disappointment! We need the original formula back! This caused severe gas and worsened my sons colic! Bring back the old total comfort! Horrible gas and increased colic from this formula! We switched for the original total comfort so we could buy the bigger tub and such a disappointment! We’ve lost so much sleep because of this formulas gas! Not okay! Bring back the original formula! We will be raiding every store to buy all the old cans we can!
Date published: 2018-08-18
Rated 1 out of 5 by from This product is absolutely horrible!! First I'll start by saying I have a set of fraternal twins and we have tried a million different formulas. My daughter has major stomach issues and has since we got home from the hospital. She alone has been on about 5 different types. We finally got on total comfort and she was tolerating it still having issues having a bowel movement, but we are on meds for that. We had went to one store and bought them out of the big cans of regular total comfort. We then decided eventually she would have to take the pro so we bought one she has been on it a day. She is literally now spitting up her entire bottle, so we are now back to square one and will have to find something she can tolerate. We cant afford her to spit up an entire bottle as she was 4lbs ar birth. She not only spits, but is gassy and will just scream in the middle of a bottle. We can find the little cans in regular total comfort are these going to continue to he available or will they be switching to pro too? I've read lots of these reviews and with WAY more negative than positive it seems you would go back to the old one.
Date published: 2018-08-17
Rated 1 out of 5 by from Should have never changed the original formula We usually buy formula in bulk so we have just recently made the transition from regular Total Comfort to Pro-Total Comfort. With two bouts of painful constipation and impacted stools it finally dawned on me that it must be the change in the formula. My daughter who is now 6 months, was briefly on Similac's Pro-Advanced formula when she came home from the hospital. Once we realized it was making her miserable and constipated we switched back to the Total Comfort she had in the hospital when she was born. Since then she's been a happy and easy baby. That was up until 2 weeks ago when she became horribly constipated. She went on medicine to get things moving only to battle another round of constipation once she was off the medicine. Currently, she is only formula fed; no solids to cause such distress on her bowels. Seems like whatever the "Pro" is, is slowing down her digestion. We've located some "regular" Total Comfort to get her past this, but we will most likely be switching over to Enfamil's Reguline formula.
Date published: 2018-08-16
Rated 1 out of 5 by from Not a good change Our baby has had tummy issues since he was born, it took us so long to find the right formula that would help with his sensitive tummy and gas pains. When we found the total comfort it was an instant change for him and he no longer had tummy issues. The last few times I've tried to buy total comfort my stores don't have it, there's not even a sick for it on the shelf anymore. I didn't have a choice but to purchase the pro total comfort since it was said to be very similar. With in a day if feeding him this we were back to no sleep with extreme fussiness and gas pains. I really hope that you bring this product back for babies that are used too this and for the ones that this is the only formula that works.
Date published: 2018-08-12
Rated 1 out of 5 by from Disappointed My 3week old was doing just fine with the original total comfort formula. I accidentally bought the pro comfort one that was suppose to be similar to the original total comfort but after 3 days of feeding my newborn with pro comfort formula he would toss and turn crying with gas and irregular bowl movements. When he was on total comfort he did just fine no gas and no problem when having bowl movements. So now I’m on the hunt to find the original total comfort because the new version pro comfort is a disappointment nothing near the same as total comfort. Not a happy mama!
Date published: 2018-08-12
Rated 5 out of 5 by from Great product for fussy babies. I noticed a significant decrease in gas and crying after 2 days of using the Similac Total Comfort. I was even more pleased to see the release of the Pro Total Comfort that is a Non-GMO product. Now mommy and baby are happy.
Date published: 2018-08-10
Rated 5 out of 5 by from Easiest Pick for Formula We were forced to make the decision to formula feed which wasn’t what I wanted to do. But since we had to we started with the same brand they used in the hospital and that was the simlac pro advance. My son then was constipted and was having the hardest night so we switched to pro total comfort and it was a sanity saver!!!! He has had no problem with bowel movements or gas!!!!
Date published: 2018-08-02
Rated 5 out of 5 by from Saved our sanity We never tried the original formula, and I can see there are several of those who preferred the original total comfort but I can’t speak to that as we started our little guy on the PRO. My son has an incredibly sensitive tummy, breastmilk had him breaking out in rashes and caused horrible reflux, when we switched to formula (pro sensitive) he tolerated it much better but after a week or two he became constipated with painful gas; I originally was unaware that PTC was more gentle than the sensitive blend and within a day of switching he cried less, was less colicky, and his painful gas significantly decreased. I also am happy they added the prebiotics for immune support! I am very satisfied with this product and thrilled to be getting great coupons each month to make it more affordable.
Date published: 2018-07-31
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