Similac® Soy Isomil®

Complete nutrition for sensitive tummies

Fussiness and gas can be a common part of feeding your baby.

Similac Soy Isomil is specially designed to comfort with the gentleness of soy to soothe the tummy.

Soy-based formulas have been clinically shown to help reduce feeding problems. No other soy-based formula has been studied more than Isomil.

Has OptiGRO to support your baby's brain and eye development.

If your baby’s fussiness or gas seems excessive, ask your physician about switching to Similac Soy Isomil.

Soy formulas are not recommended for premature infants with birth weights of less than 1800 g.

Similac Soy Isomil formula product for infants

Available In:

1.45-lb Powder

12.4-oz Powder

1-qt Ready to Feed

Soy for fussiness and gas

Nutrition Information

Powder / 1.45 lb

Serving size: 100 Cal (prepared as directed)*

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

* Nutrient values are applicable when prepared as directed.

Similac® Soy Isomil®
Similac logo

New Moms

Join Similac® StrongMoms® Rewards for up to $400* in customized benefits, free gifts, and exclusive savings.
Strongmom Decor Dsk
SIGN UP * Offers may vary.

Similac Soy Isomil Reviews

Rated 5 out of 5 by from So gentle My daughter was put on pro-advance at the hospital when I wasn’t producing enough milk. Then the pediatrician put her on total comfort at 3 weeks old. Now at 8 months she was still having terrible reflux and stomach discomfort. I did some research and felt soy was worth giving a try. It’s been about a week on Isomil and I can tell she’s having less reflux and it seems so gentle on her belly.
Date published: 2019-01-21
Rated 5 out of 5 by from Works great!!! I just purchased the milk today and gave my daughter two bottles so far. When i say it works wonders it works wonders!!! She was on breast milk then when she wasnt gaining weight off my milk i supplemented with the pro advantage. The pro advanted had her constipated and she was always hungry,fussy and gassy. I switched to the pro sensitive she was no longer constipated but she still stayed hungry and was more fussy and gassy to where i couldnt sleep n the pacifier wasnt working. Today i decided to put her on soy n she has been full after her feeding she wasnt crying like she normally do she was quiet looking around and smiling. When it was time for her to go to sleep she went to sleep with no problems. She wasnt crying and didnt even need her pacifier. She sooooo calm i keep checking to make sure she okay lol. I love this milk so far!!!!!!
Date published: 2019-01-19
Rated 5 out of 5 by from This product worked well with all 3 of my children With all three of my children, Similac Soy has been our formula of choice and has settled the best in their stomachs. I highly recommend this product, especially if your infant experiences gassiness.
Date published: 2019-01-15
Rated 5 out of 5 by from Amazing Best thing to happen to our household! I have a new baby with the help of this formula
Date published: 2019-01-03
Rated 5 out of 5 by from Great Product My daughter has been on this since 3 Months old she was having tummy issues so we tried it and it was like magic in a bottle! But she is now 10 Months and I am looking for a toddler transition formula that’s milk and lactose free can anyone help me with that? Or do I just keep feeding this formula?
Date published: 2018-12-07
Rated 4 out of 5 by from Made all the difference in the world My baby was born premature weighting just over 3lbs at birth. He never mastered the latch and I never produced enough milk for him so formula became or best friend. We tried several brands and types of formula, including other similac products but has the same result with all of them, Gassiness, fussing like he was in pain, constipation, loads of spit up, and show weight gain even though he was in a high calorie diet. After 2 months I finally asked my pediatrician about isomil because it was the only formula I could handle a a baby according to my mom. The doctor said normally they don't recommend it with preemies but since he was having issues let's try it. Within 2 days I noticed a difference, no fussiness, very little spit up and gas, and no more constipation. Also he started gaining weight. Where most babies double they're birth weight by 6 months old he has more than quadrupled his, now weighing over 14lbs. I have no doubt in my mind that if we didn't switch to isomil he would still be struggling to gain weight. My only complaint is that it's so expensive, we go through the 1.45lb the of isomil every 4 days and even through I've signed up for coupons I've only received them once and it's been over six months and even then the coupons were for neosure so I couldn't use them. Over all through it's a great product.
Date published: 2018-12-03
Rated 5 out of 5 by from Only formula that worked We had a very fussy, gassy, bearing down baby after trying Similac pro advance, pro sensitive, and enfamil gentle ease. All of these caused her great discomfort. We tried gripe water, gas drops etc. Similac Soy Isomil was the ONLY thing that worked!! No more fussy! When she was newborn- 2 months she did get constipated so we did add a little Gerber apple juice to her bottles which helped. But this formula is a life saver and my 6 month old is now a happy, right on track baby!
Date published: 2018-11-25
Rated 5 out of 5 by from Really helped my son’s sensitive tummy My LO had really bad stomach cramps, very gassy, and could not tolerate the similac Alimentum. After switching to the soy Isomil we no longer have any issues. Thanks to the soy formula my LO can finally be comfortable and rest peacefully
Date published: 2018-11-21
  • y_2019, m_2, d_22, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.11
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_243
  • loc_en_US, sid_sim-prod-420, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING), SortEntry(order=FEATURED, direction=DESCENDING)]
  • clientName_similac
  • bvseo_sdk, net_sdk,
  • CLOUD, getReviews, 47ms