Similac® Soy Isomil®

Complete nutrition for sensitive tummies

Fussiness and gas can be a common part of feeding your baby.

Similac Soy Isomil is specially designed to comfort with the gentleness of soy to soothe the tummy.

Soy-based formulas have been clinically shown to help reduce feeding problems. No other soy-based formula has been studied more than Isomil.

Has OptiGRO to support your baby's brain and eye development.

If your baby’s fussiness or gas seems excessive, ask your physician about switching to Similac Soy Isomil.

Soy formulas are not recommended for premature infants with birth weights of less than 1800 g.

Similac Soy Isomil formula product for infants

Available In:

Similac Soy Isomil 1.45lb formula for infants 1.45-lb Powder

Similac Soy Isomil 12.4oz formula for infants 12.4-oz Powder

Similac Soy Isomil 32oz formula for infants 1-qt Ready to Feed

Nutrition Information

Powder / 1.45 lb

Serving size: 100 Cal (prepared as directed)*

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

* Nutrient values are applicable when prepared as directed.

Similac® Soy Isomil®
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Rated 5 out of 5 by from It's AMAZING My son started out on Similac in the blue can which made him very constipated. So we switch him to Similac Soy and it is AMAZING! No more constipation.
Date published: 2017-07-22
Rated 5 out of 5 by from Best Option For Our Baby After 36 hours of our baby crying after taking each sip and then spitting up everything in his bottle at the hospital as a newborn, soy was a last resort for us (while in he hospital). With the first sip, we knew that this formula was going to be the one. Thank you Similac for creating such a great product and for making our baby boy happy!
Date published: 2017-07-21
Rated 3 out of 5 by from Gave my baby terrible gas and constipation My son is 3 weeks old and has colic due to milk allergies. I tried this formula to help relieve his tummy problems with feeding. It made him worst. The formula gave him terrible gas and made him constipated. Now I'm lost on what formula to try next.
Date published: 2017-06-29
Rated 2 out of 5 by from Did not work for my little one I've been breastfeeding my son since he was born. He's almost 5 months now and I'm slowly switching him to formula and I'm having a hard time looking for formula that works for him. The regular formula gave him hives and bloody stool. My pediatrician recommended soy and so I tried Similac Soy Isomil for about two weeks now. I give him 1 Similac Soy Milk (about 3.5 oz) per day just to start. Every time I give him Similac Soy Isomil, he will either have a projectile vomit or a major spit up after each feeding. He also gets super constipated. I switched him back to breastmilk full time and he tolerated breastmilk with no issues and pooped without straining. So I know it was the soy milk that was causing it. I don't have enough breastmilk for him and so I'm trying to figure out what other alternatives I have.
Date published: 2017-06-27
Rated 4 out of 5 by from Good but not great I have a 4 month old daughter and we have tried just about every Similac formula there is. We started with the supplementation formula while I was still breastfeeding, then switched to Similac Sensitive when I stopped breastfeeding due to excessive spit up and her being gassy all of the time. About the same time, her pediatrician prescribed Xantax for reflux. She was still very gassy and going through multiple changes of clothes each day from so much spit up, so we tried the Similac Total Comfort. No change. We then tried the Similac Soy Isomil. Drastic improvement for spit up, but now she is waking at around 2 am every morning grunting and crying as if her belly hurts and won't go back to sleep. On all of the other forumals we tried, she has slept through the night. So, we tried Similac Alimentum hoping that would do the trick - it would help with the spit up like the Soy formula did but also help her to start sleeping through the night again. No such luck, she refused to eat the Alimentum. About the only formula we haven't tried yet is the Similac Spit Up, but we aren't sure if it's even worth trying. It seems as though our choices are excessive gas and spit up or hardly any spit up at all but waking at 2 am every morning. Since you can't purchase sample sizes, we have been left with a huge hole in our wallet and a pantry full of partially used formulas! Offering sample sizes for purchase would be great for families like us who just can't seem to find the right formula for our daughter.
Date published: 2017-06-25
Rated 5 out of 5 by from this product is a lifesaver This Similac soy saved my baby's butt. My poor baby from the time he was born for the first three or four weeks of his life had a raw butt and we could not figure out what was causing it until his doctor switched him to Similac soy and as soon as we switchef him it went away
Date published: 2017-06-23
Rated 5 out of 5 by from This formula is a life saver!!! Oh wow, I don't even know where to begin. Our little boy was severe colic starting at 2 weeks old. Crying all day every day for 4 months straight, it was HORRIBLE.He was also having blood in his stool because he had a milk protein allergy that we didnt discover until he was about 4 months old. We tried 6 different formulas and Similac Soy was our seventh formula. And FINALLY the blood in his stool stopped and after a few days of being on it, he was SO much happier and actually sleeping. A completely different baby!!! I can't thank Similac enough for making this saved our sanity, which sounds dramatic, but if you've ever had a colicky baby you know what I'm talking about. If you're baby has a milk protein allergy, try this formula!! I know most babies allergic to milk are also allergic to soy, but not ours. In fact, he couldn't even tolerate all of the hypoallergenic formulas. This formula is a LIFE SAVER!!! We are happy and our baby is happy!!
Date published: 2017-06-17
Rated 5 out of 5 by from Love this formula My son is 4 weeks old and he was eating Gerber Goodstart Gentle and he was spitting up all of it half an hour after feedings. We switched to Similac Isomil and he didn't have any trouble! He loves it and he isn't fussy especially during the nighttime feedings. It's easy on his tummy as well.
Date published: 2017-06-15
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