Similac Total Comfort

For discomfort due to persistent feeding issues

If your baby is experiencing discomfort due to persistent feeding issues, Similac Total Comfort may help.

Partially broken-down protein promotes easy digestion.

Has OptiGRO to support your baby's brain and eye development.

Similac Total Comfort powder formula for infants

Available In:

Similac Total Comfort powder formula for infants 1.41-lb Powder

Similac Total Comfort 12oz formula for infants 12.0-oz Powder

Nutrition Information

Powder / 1.41 lb

Serving size: 100 Cal

Amount per serving

  • Calories:


  • Volume, mL:


  • Protein, g:


  • Fat, g:


  • Carbohydrate, g:


  • Water, g:


  • Linoleic Acid, mg:


Vitamins & Minerals

Similac Total Comfort™
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Rated 5 out of 5 by Great Formula We switched to Similac Total Comfort after using Similac Sensitive. Baby was having trouble pushing out a bowel movement, and he was starting to get constipated. This formula works better than the sensitive, but we still have to have a bottle of Enfamil reguline once a day which gets/keeps things moving for baby. I wish the Total Comfort came in ready-to-feed bottles like other Similac formulas (I saw there were some on amazon, but they're not by the Similac brand so I don't trust it). It would also be nice to get coupons for this formula as it can be rather expensive. Bottom line: I would definitely recommend this product for babies with feeding issues. February 3, 2016
Rated 4 out of 5 by Constipation gone I had to change the Similac Advanced to Similac for Discomfort because my son began to experience constipation. This was at 3 months and he is now 5 months. You have to give the babys tummy time to adjust to the new milk. After the change, in just a few days my son began to have his normal 2 to 3 bowel movements a day. But what I don't like about this milk is that it doesnt come in a bigger container. I wish it came larger like the similac advanced. February 3, 2016
Rated 4 out of 5 by Still not sure if this is the right formula for us... My 3 month old was started on Similac Advanced and was switched to Similac Sensitive at 1 month due to her being very gassy, fussy and spitting up frequently. We tried Similac spitup but this didn't agree with her. We've now been on Total Comfort for 1 1/2 months. Her gas has gotten better but the frequent spitting up and fussiness has not changed. Over all this is a very good formula but I'm not convinced this is the best for my daughter. February 2, 2016
Rated 5 out of 5 by Great for my reflux baby! This is my 4th attempt with formula and was my last similac before opting to try a different brand to see if it would help my baby. He's on two different reflux medications and with being back to work, had to start formula quicker than I hoped because I just wasn't pumping enough. Everything we tried made him spit up more and more. Finally decided to try total comfort before switching and trying enfomil and so glad we did! He's been on it almost a week now and we have noticed a significant difference. No more spitting up at night and only the occasional light spit up during the day... But I think that's more of a reflux issue than formula because he spit up still a bit on breast milk. I do have to admit the only downfall is like other reviewers have stated- it really is too bad that it doesn't come in larger/cheaper containers. This miracle worker does come at a hefty price. He goes through almost an entire container in one week. Hopefully with the feedback similac will look into making larger cans so it's more affordable for those of us who need it! January 28, 2016
Rated 5 out of 5 by The Only Formula My Daughter's Tummy Agrees With One of my fraternal twin daughters (now 4 months old) has had stomach issues since birth. She started out as a breastfed baby and was having constant diarrhea. Her pediatrician diagnosed her with a milk protein allergy, but she continued to have issues even after cutting dairy out of my diet. Our doctor recommended Similac Alimentum, but she was not a fan of the taste. We kept trying for a few days, but she started refusing the bottle and losing weight (she was already small as she was almost 3 weeks premature). We also tried Similac Isomil and Sensitive, but those didn't work either as she was spitting most of it up. We then switched to Enfamil Gentlease and she became SEVERELY constipated. Finally, we switched to Similac Total Comfort and her stomach issues resolved almost instantly. She now looks forward to her bottle and is a happy baby who rarely spits up and has regular bowel movements. So glad we found Similac Total Comfort! I wish it came in the on-the-go bottles and in bulk size. I would buy it all! January 26, 2016
Rated 5 out of 5 by Helped with constipation My daughter was on Enfamil Newborn from the day she was born till about 2 weeks old and was having terrible bowel movement problems. We then switched to Similac Sensitive and it helped a little bit but she went back to having trouble. My husband would have to put pressure on her tummy, move her legs around, rub her back. But nothing was working. The pediatrician recommended Similac Total Comfort and it has been our miricle formula. She had a bowel movement by herself after a week! I've never felt this excited about this kind of stuff before. January 22, 2016
Rated 5 out of 5 by Great for my Reflux baby! My poor little one suffers from Reflux and she was breastfed and we used advance and sensitive but it left her constipated. She did well on the formula for supplementation as I was breastfeeding as well. Due to the Reflux issues I had to stop and her doctor started her on Zantac we switched to the formula for spit up and she Hated it. We now use Total comfort and it is like a miracle worker! January 9, 2016
Rated 5 out of 5 by Finally a keeper My daughter has been on 5 Similac Formulas. Advance, Supplement, Soy, Sensitive & Total Comfort. Due to her acid reflux, the Advance, Supplement and Soy did not work for her. The sensitive worked for her reflux, but severely constipated her. After 5 months of trying different formulas, her doctor recommended Similac Total Comfort. It has been AMAZING! She rarely spits up anymore, and has normal BMS now. I am very grateful to have finally found a formula to work for my daughter! The only compliant I could have, is that it is only Available at 1 store (Walmart)in the city we live in. However I would definitely recommend using this product, especially if you have a formula troubled child like mine (: January 7, 2016
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